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The X-Chromosomal STRs in Forensic Genetics: X Chromosome STRs
| Content Provider | Scilit |
|---|---|
| Author | Pereira, Vânia Gusmão, Leonor |
| Copyright Year | 2021 |
| Description | Because of the unique transmission properties, markers located in the X chromosome are an important tool in the field of forensic genetics, more specifically in kinship analysis. In the majority of the casework presented in forensics, the autosomal markers are the most informative and most widely used, since they present the highest power of discrimination among individuals within a population. However, situations arise where markers located in other regions of the genome can be more informative and should be used instead to complement autosomal information. This is the case of mtDNA, for example, that has a prominent role in the analysis of ancient or degraded samples, due to the high number of copies present in each cell. In contrast, the Y-chromosome-specific markers are more suitable than autosomal to recover male genetic profiles in mixtures with high amounts of female DNA. The X-chromosome-specific markers represent the best choice in kinship cases where the information provided by autosomal markers alone is not sufficient. The presence of only one X chromosome in males that does not suffer recombination during meiosis and that is transmitted to all female descendants as a haplotype has proven to be of great importance in cases 92where autosomal markers have no power of exclusion, namely to investigate paternal half-sisters or paternal grandmother/granddaughter relationships. While X-chromosomal markers present obvious advantages in some forensic scenarios, a certain degree of complexity arises in the statistical interpretation of genetic evidence from linked markers. The present chapter will briefly introduce the X chromosome as an important tool in forensic genetics and will present the main characteristics of this type of markers when applied to kinship analysis. Book Name: Forensic DNA Analysis |
| Related Links | https://content.taylorfrancis.com/books/download?dac=C2020-0-12705-7&isbn=9781003043027&format=googlePreviewPdf |
| DOI | 10.1201/9781003043027-7 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2021-01-29 |
| Access Restriction | Open |
| Subject Keyword | Book Name: Forensic Dna Analysis Legal Medicine Number of Copies Forensic X Chromosome Kinship Analysis Autosomal Chromosome Are an Important Tool |
| Content Type | Text |
| Resource Type | Chapter |
