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Circulating Tissue Factor-Positive Procoagulant Microparticles in Patients with Type 1 Diabetes
| Content Provider | Scilit |
|---|---|
| Author | Zhang, Chenghui Ou, Qing Gu, Yan Cheng, Gaiping Du, Rong Yuan, Li Cordiner, Ruth Lm Kang, Deying Zhang, Jiaying Huang, Qiaorong Yu, Chuan Kang, Li Wang, Xuan Sun, Xin Mo, Xianming Tian, Haoming Pearson, Ewan Meng, Wentong Li, Sheyu |
| Copyright Year | 2020 |
| Description | Aim: To investigate the count of circulating tissue factor-positive $(TF^{+}$) procoagulant microparticles (MPs) in patients with type 1 diabetes mellitus (T1DM). Methods: This case-control study included patients with T1DM and age and sex-matched healthy volunteers. The counts of phosphatidylserine-positive $(PS^{+}$) MPs and $TF^{+}PS^{+}$MPs and the subgroups derived from different cell types were measured in the peripheral blood sample of the two groups using multicolor flow cytometric assay. We compared the counts of each MP between groups as well as the ratio of the $TF^{+}PS^{+}$MPs and $PS^{+}$MPs $(TF^{+}PS^{+}MPs/PS^{+}$MPs). Results: We recruited 36 patients with T1DM and 36 matched healthy controls. Compared with healthy volunteers, $PS^{+}$MPs, $TF^{+}PS^{+}$MPs and $TF^{+}PS^{+}MPs/PS^{+}$MPs were elevated in patients with T1DM $(PS^{+}$MPs: 1078.5 ± 158.08 vs 686.84 ± 122.04/μL, P <0.001; $TF^{+}PS^{+}$MPs: 202.10 ± 47.47 vs 108.33 ± 29.42/μL, P <0.001; and $TF^{+}PS^{+}MPs/PS^{+}$MPs: 0.16 ± 0.04 vs 0.19 ± 0.05, P = 0.004), mostly derived from platelet, lymphocytes and endothelial cells. In the subgroup analysis, the counts of total and platelet $TF^{+}PS^{+}$MPs were increased in patients with diabetic retinopathy (DR) and with higher HbA1c, respectively. Conclusion: Circulating $TF^{+}PS^{+}$MPs and those derived from platelet, lymphocytes and endothelial cells were elevated in patients with T1DM. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978680/pdf https://www.dovepress.com/getfile.php?fileID=55090 |
| Ending Page | 2828 |
| Page Count | 10 |
| Starting Page | 2819 |
| ISSN | 11787007 |
| DOI | 10.2147/dmso.s225761 |
| Journal | Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy |
| Volume Number | 12 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2020-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Endocrinology and Metabolism Integrative and Complementary Medicine Diabetic Retinopathy Microparticles Tissue Factor Type 1 Diabetes Mellitus |
| Content Type | Text |
| Resource Type | Article |
| Subject | Internal Medicine Pharmacology |
