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Spatiotemporal organization and mechanosensory function of podosomes
| Content Provider | Scilit |
|---|---|
| Author | Dries, Koen Van Den Bolomini-Vittori, Matteo Cambi, Alessandra |
| Copyright Year | 2014 |
| Description | Podosomes are small, circular adhesions formed by cells such as osteoclasts, macrophages, dendritic cells, and endothelial cells. They comprise a protrusive actin core module and an adhesive ring module composed of integrins and cytoskeletal adaptor proteins such as vinculin and talin. Furthermore, podosomes are associated with an actin network and often organize into large clusters. Recent results from our laboratory and others have shed new light on podosome structure and dynamics, suggesting a revision of the classical "core-ring" model. Also, these studies demonstrate that the adhesive and protrusive module are functionally linked by the actin network likely facilitating mechanotransduction as well as providing feedback between these two modules. In this commentary, we briefly summarize these recent advances with respect to the knowledge on podosome structure and discuss force distribution mechanisms within podosomes and their emerging role in mechanotransduction. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.4161/cam.28182?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198351/pdf |
| Ending Page | 272 |
| Page Count | 5 |
| Starting Page | 268 |
| ISSN | 19336918 |
| e-ISSN | 19336926 |
| DOI | 10.4161/cam.28182 |
| Journal | Cell adhesion & migration |
| Issue Number | 3 |
| Volume Number | 8 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2014-02-20 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cell Adhesion & Migration Cell Biology Actin Cell Adhesion Invadopodia Mechanotransduction Podosome Tension |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Cellular and Molecular Neuroscience |
