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PtdIns(3,4)P2 instigates focal adhesions to generate podosomes
| Content Provider | Scilit |
|---|---|
| Author | Oikawa, Tsukasa Takenawa, Tadaomi |
| Copyright Year | 2009 |
| Description | Cell-to-extracellular matrix (ECM) adhesion plays important roles in various biological events, such as proliferation, differentiation and migration. Distinct from other types of adhesion structures (focal complexes, focal adhesions and so on), podosomes and invadopodia are thought to have additional functions beyond attachment, possibly including invasion into the ECM. For podosomes and invadopodia to invade into the ECM, molecules involved in adhesion, actin polymerization and ECM degradation must be recruited to sites of action. Our recent study demonstrated that podosomes form near newly formed focal adhesions via the minimally expressed phosphoinositide PtdIns(3,4) P2-mediated recruitment of the Tks5-Grb2 scaffold, followed by the accumulation of N-WASP. Although this study demonstrated details of molecular interplay during the transformation of focal adhesion, its regulation in the in vivo invasion process remains to be clarified. Here, we discuss the molecular bases of the transformation of focal adhesions to podosomes/invadopodia based on current understanding. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.4161/cam.3.2.7510?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679885/pdf https://www.landesbioscience.com/journals/celladhesion/OikawaCAM3-2.pdf |
| Ending Page | 197 |
| Page Count | 3 |
| Starting Page | 195 |
| ISSN | 19336918 |
| e-ISSN | 19336926 |
| DOI | 10.4161/cam.3.2.7510 |
| Journal | Cell adhesion & migration |
| Issue Number | 2 |
| Volume Number | 3 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2009-04-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cell Adhesion & Migration Biochemistry and Molecular Biology Cell Biology Podosome Invadopodium Focal Adhesion Tks5 Ptdins(3,4)p2 N-wasp |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Cellular and Molecular Neuroscience |
