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The evolution into personalized therapies in pancreatic ductal adenocarcinoma: challenges and opportunities
| Content Provider | Scilit |
|---|---|
| Author | Tesfaye, Anteneh A. Kamgar, Mandana Azmi, Asfar Philip, Philip A. |
| Copyright Year | 2017 |
| Description | Pancreatic ductal adenocarcinoma (PDAC) is projected to be the second leading cause of cancer related mortality in the United States in 2030, with a 5-year overall survival of less than 10% despite decades of extensive research. Pancreatic cancer is marked by the accumulation of complex molecular changes, complex tumor-stroma interaction, and an immunosuppressive tumor microenvironment. PDAC has proven to be resistant to many cytotoxic, targeted and immunologic treatment approaches. In this paper, we review the major areas of research in PDAC, with highlights on the challenges and areas of opportunity for personalized treatment approaches. The focus of research in pancreatic cancer has moved away from developing conventional cytotoxic combinations. The marked advances in understanding the molecular biology of this disease especially in the areas of the microenvironment, metabolism, and DNA repair have opened new opportunities for developing novel treatment strategies. Improved understanding of molecular abnormalities allows the development of personalized treatment approaches. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121777/pdf |
| Ending Page | 148 |
| Page Count | 18 |
| Starting Page | 131 |
| ISSN | 14737140 |
| e-ISSN | 17448328 |
| DOI | 10.1080/14737140.2018.1417844 |
| Journal | Expert Review of Anticancer Therapy |
| Issue Number | 2 |
| Volume Number | 18 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2018-02-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Expert Review of Anticancer Therapy Gastroenterology and Hepatology Targeted Therapy Personalized Therapy Pancreas Cancer Tumor Microenvironment Dna Repair Pathways |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) Oncology |
