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Targeted Therapies for Pancreatic Cancer: Overview of Current Treatments and New Opportunities for Personalized Oncology
| Content Provider | MDPI |
|---|---|
| Author | Leroux, Cédric Konstantinidou, Georgia |
| Copyright Year | 2021 |
| Description | Cytotoxic chemotherapy remains the only treatment option for most pancreatic ductal adenocarcinoma patients. Currently, the median overall survival of patients with advanced disease rarely exceeds 1 year. The complex network of pancreatic cancer composed of immune cells, endothelial cells, and cancer-associated fibroblasts confers intratumoral and intertumoral heterogeneity with distinct proliferative and metastatic propensity. This heterogeneity can explain why tumors do not behave uniformly and are able to escape therapy. The advance in technology of whole-genome sequencing has now provided the possibility of identifying every somatic mutation, copy-number change, and structural variant in a given cancer, giving rise to personalized targeted therapies. In this review, we provide an overview of the current and emerging treatment strategies in pancreatic cancer. By highlighting new paradigms in pancreatic ductal adenocarcinoma treatment, we hope to stimulate new thoughts for clinical trials aimed at improving patient outcomes. |
| Starting Page | 799 |
| e-ISSN | 20726694 |
| DOI | 10.3390/cancers13040799 |
| Journal | Cancers |
| Issue Number | 4 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-02-14 |
| Access Restriction | Open |
| Subject Keyword | Cancers Oncology Pancreatic Ductal Adenocarcinoma Therapies Dna Repair Tumor Microenvironment Epigenetic Alterations Key Mutations Autophagy Immunotherapy |
| Content Type | Text |
| Resource Type | Article |
