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Efficacy of a Polyvalent Inactivated-virus Vaccine in Protecting Mice from Infection with Clinical Strains of Group B Coxsackieviruses
| Content Provider | Scilit |
|---|---|
| Author | See, Darryl M. Tilles, Jeremiah G. |
| Copyright Year | 1994 |
| Description | A polyvalent vaccine developed from formalin-inactivated prototype strains of coxsackieviruses group B1–6 was tested for its ability to protect mice from acute infection with clinical strains. Adolescent male CD1 mice received an intraperitoneal injection, repeated once or twice at 8 day intervals, containing 0.3 ml placebo or vaccine. Eight days after the final dose of vaccine, groups of 4 mice were challenged with 1 × 104 plaque-forming units of a test strain of group B coxsackievirus, and killed 3 days later. The mean neutralizing antibody titers for the 29 strains tested (4 mice/strain, Iog2) were 2.2 ± 0.6, 3.3 ± 0.9 or 6.4 ± 1.7 after 1, 2 or 3 doses of vaccine, respectively. In mice receiving 2 or 3 doses of vaccine, titers of virus were significantly lower in the pancreas and/or blood in 7/14 or 14/15 strains, respectively, compared to unvaccinated infected controls. Uninfected, vaccinated mice failed to develop islet cell autoantibodies, histopathological abnormalities in the pancreas, or evidence of viral RNA in the pancreas 12 weeks after 3 doses of vaccine. Thus, prophylaxis with a polyvalent, inactivated-virus vaccine reduced the severity of acute infection with clinical strains of coxsackie group B viruses. A schedule of 3 doses of vaccine was superior to 1 or 2 doses. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/00365549409008644 |
| Ending Page | 747 |
| Page Count | 9 |
| Starting Page | 739 |
| ISSN | 00365548 |
| e-ISSN | 16511980 |
| DOI | 10.3109/00365549409008644 |
| Journal | Scandinavian journal of infectious diseases |
| Issue Number | 6 |
| Volume Number | 26 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1994-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Scandinavian Journal of Infectious Diseases Infectious Diseases Efficacy Polyvalent Inactivated Clinical Strains Coxsackieviruses Virus Vaccine Inactivated Virus Protecting Mice |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Immunology and Microbiology Microbiology (medical) |
