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The Effect of Recompression on Disintegrant Efficiency in Tablets Prepared by wet Granulation
| Content Provider | Scilit |
|---|---|
| Author | Gould, P. L. Tan, S. B. |
| Copyright Year | 1985 |
| Description | The efficiency of three modern disintegrants, Explotab, Ac-Di-Sol and Polyplasdone XL, has been investigated following rework of a wet massed, slowly eroding, tablet formulation. When the disintegrants were placed extra-granularly it was found that only Explotab retained good efficiency following rework. All disintegrants placed intra-granularly had rework efficiencies that were essentially the same as the control (no disintegrant). However, the addition of 2% extra-granular disintegrant prior to the second compression restored tablet disintegration behaviour for Polyplasdone XL and partially for Ac-Di-Sol. Two of the factors potentially affecting the reworkability of disintegrants (comminution and regranulation) were also investigated. Regranulation caused Ac-Di-Sol and Explotab to significantly lose disintegrant efficiency. However milling alone caused no reduction in efficiency of any disintegrant. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/03639048509056880 |
| Ending Page | 460 |
| Page Count | 20 |
| Starting Page | 441 |
| ISSN | 03639045 |
| e-ISSN | 15205762 |
| DOI | 10.3109/03639048509056880 |
| Journal | Drug Development and Industrial Pharmacy |
| Issue Number | 2-3 |
| Volume Number | 11 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1985-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Drug Development and Industrial Pharmacy Legal Medicine Disintegrant Efficiency Wet Granulation Tablets Prepared Effect of Recompression |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science |
