NDLI: miR-765 Acts as a Tumor Promoter and Indicates Poor Prognosis in Non-Small Cell Lung Cancer

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miR-765 Acts as a Tumor Promoter and Indicates Poor Prognosis in Non-Small Cell Lung Cancer

Content Provider	Scilit
Author	Wang, Jiying Wang, Li Zhang, Congjun
Copyright Year	2021
Description	Purpose: Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related death worldwide with poor prognosis. Accumulating evidence indicates that miR-765 is an important regulator in the progression and prognosis of various cancers. In this study, the function in the progression and prognosis of NSCLC was investigated. Patients and Methods: The expression of miR-765 in NSCLC was analyzed by qRT-PCR. The effect of miR-765 on cell proliferation, migration, and invasion of NSCLC was evaluated by CCK8 and Transwell assay. Kaplan–Meier analysis and Cox regression analysis were employed to assess the prognostic value of miR-765. Results: The results demonstrated the significant upregulation of miR-765 in NSCLC tissues and cell lines relative to normal tissues and cells. High miR-765 expression was significantly correlated with the TNM stage of patients. Patients with high miR-765 expression showed a poorer prognosis than that of patients with low miR-765 expression. Cox analysis indicated that miR-765 could be considered as an independent prognostic factor for NSCLC. Additionally, the upregulation of miR-765 was revealed to promote NSCLC cell proliferation, migration, and invasion by targeting BMP6. Conclusion: The overexpression of miR-765 in NSCLC was associated with TNM stage and poor prognosis of patients. miR-765 served as a tumor promoter of NSCLC by regulating BMP6. These findings provide a potential biomarker and therapeutic target for the prognosis and treatment of NSCLC.
Related Links	https://www.dovepress.com/getfile.php?fileID=72292
Ending Page	4343
Page Count	9
Starting Page	4335
ISSN	11786930
DOI	10.2147/ott.s284212
Journal	OncoTargets and therapy
Volume Number	14
Language	English
Publisher	Informa UK Limited
Publisher Date	2021-08-01
Access Restriction	Open
Subject Keyword	Journal: Oncotargets and Therapy Oncology Non-small Cell Lung Cancer Mir-765 Prognosis Progression
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical) Oncology

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miR-765 Acts as a Tumor Promoter and Indicates Poor Prognosis in Non-Small Cell Lung Cancer

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