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A comparative study of dydrogesterone and micronized progesterone for luteal phase support duringin vitrofertilization (IVF) cycles
| Content Provider | Scilit |
|---|---|
| Author | Saharkhiz, Nasrin Zamaniyan, Marzieh Salehpour, Saghar Zadehmodarres, Shahrzad Hoseini, Sedighe Cheraghi, Leila Seif, Samira Baheiraei, Nafiseh |
| Copyright Year | 2015 |
| Description | The aim of the present study was to compare the efficacy, tolerability and patients' satisfaction after the use of oral dydrogesterone with vaginal micronized progesterone for luteal-phase support (LPS) among infertile women undergoing in vitro fertilization (IVF). A total of 210 women (aged 20-40 years old) with a history of infertility, who underwent controlled ovarian stimulation for fresh intra-cytoplasmic sperm injection-embryo transfer cycles, were included in the study. Consequently, they were randomized to receive LPS with dydrogesterone 20 mg twice daily (n = 96) or micronized progesterone 400 mg twice daily at the day of oocyte retrieval (n = 114). The clinical success rate (31% versus 33%; p = 0.888), miscarriage rate (5.0% versus 3.0%; p = 0.721), ongoing pregnancy rate (30.0% versus 30.0%; p = 1.000), implantation (22.0% versus 24.0%; p = 0.254) and multiple pregnancy rate (5.30% versus 7.20%; p = 0.394) were comparable among the two groups. Serum progesterone levels were significantly lower among the patients receiving dydrogesterone than the control group (13.62 ± 13.83 ng/ml versus 20.66 ± 18.09 ng/ml; p = 0.001). However, there was no statistically significant difference regarding the patients' satisfaction (p = 0.825) and tolerability (0.790) between the two groups. Our results showed that oral dydrogesterone (40 mg/day) is as effective as vaginal micronized progesterone considering its clinical outcomes and patients' satisfaction and tolerability, for LPS among women undergoing IVF. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/09513590.2015.1110136 |
| Ending Page | 217 |
| Page Count | 5 |
| Starting Page | 213 |
| ISSN | 09513590 |
| e-ISSN | 14730766 |
| DOI | 10.3109/09513590.2015.1110136 |
| Journal | Gynecological Endocrinology |
| Issue Number | 3 |
| Volume Number | 32 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2015-11-16 |
| Access Restriction | Open |
| Subject Keyword | Journal: Gynecological Endocrinology Andrology Reproductive Biology in Vitro Fertilization |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Endocrinology Obstetrics and Gynecology |
