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Combined progesterone (IM + V) versus vaginal progesterone for luteal support in cleavage-stage embryo transfer cycles of good prognosis patients
| Content Provider | Scilit |
|---|---|
| Author | Pabuccu, E. G. Pabuccu, R. Ozdegirmenci, O. Evliyaoglu Durmus, A. Bostancı Keskin, M. |
| Copyright Year | 2015 |
| Description | Many reports led to the consensus on the use of progesterone (P) for luteal-phase support. Vaginal P application is the method of choice due to its simplicity and high patient convenience but is hampered by application difficulties and personal or cultural aversions. Inappropriate vaginal P use may alter successful implantation, leading physicians to consider alternate P application routes. A worldwide survey revealed that intramuscular plus vaginal P (combined P) is the method used in nearly one-third of in vitro fertilization (IVF) cycles, particularly in Asia and North America; unfortunately, the outcomes of this approach have not been clearly elucidated. In the current analysis, we evaluated any additional benefit of short course parenteral P in addition to vaginal P capsules during a specific period in terms of implantation, pregnancy rates, miscarriages and ectopic pregnancies in cleavage stage embryo transfer (ET) cycles of good-prognosis patients. Despite significantly higher implantation rates in the combined arm, clinical and ongoing pregnancies were comparable in both groups, whereas a trend toward increased pregnancy rates was observed with combined support. The available data are too limited to draw conclusions. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.3109/09513590.2015.1127910 |
| Ending Page | 369 |
| Page Count | 4 |
| Starting Page | 366 |
| ISSN | 09513590 |
| e-ISSN | 14730766 |
| DOI | 10.3109/09513590.2015.1127910 |
| Journal | Gynecological Endocrinology |
| Issue Number | 5 |
| Volume Number | 32 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2016-05-03 |
| Access Restriction | Open |
| Subject Keyword | Journal: Gynecological Endocrinology Reproductive Biology Antagonist Icsi Implantation Luteal Phase Progesterone |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Endocrinology Obstetrics and Gynecology |
