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Commensal regulation of T cell survival through Erdr1
| Content Provider | Scilit |
|---|---|
| Author | Weis, Allison M. Soto, Raymond Round, June L. |
| Copyright Year | 2018 |
| Description | The commensal microbiota influences many aspects of immune system regulation, including T cells, but molecular details of how this occurs are largely unknown. Here we review our findings that the microbiota regulates Erdr1, a secreted apoptotic factor, to control T cell survival. Erdr1 is highly upregulated in CD4+ T cells from germfree mice and antibiotic treated animals, and our study shows that Erdr1 is suppressed by the microbiota via Toll-like receptor signaling and MyD88 dependent pathways. Erdr1 functions in an autocrine fashion and promotes apoptosis through the FAS/FASL pathway. Suppression of Erdr1 leads to survival of autoreactive T cells and exacerbated autoimmune disease in the EAE model, and overexpression of Erdr1 results in lessened disease. This novel T cell apoptotic factor has implications for autoimmunity, cancer biology, and invasive pathogens and thus represents a novel therapeutic target in disease. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.1080/19490976.2018.1441662?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219650/pdf |
| Ending Page | 7 |
| Page Count | 7 |
| Starting Page | 1 |
| ISSN | 19490976 |
| e-ISSN | 19490984 |
| DOI | 10.1080/19490976.2018.1441662 |
| Journal | Gut Microbes |
| Issue Number | 5 |
| Volume Number | 9 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2018-03-15 |
| Access Restriction | Open |
| Subject Keyword | Journal: Gut Microbes Immunology Research and Experimental Medicine Erdr1 Host-pathogen Interactions T Cells Tlrs Autoimmunity Microbiota |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Gastroenterology Microbiology Microbiology (medical) |
