NDLI: Mass Spectrometric Bioanalysis Assisted by Noble Metal Nanoparticles

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Mass Spectrometric Bioanalysis Assisted by Noble Metal Nanoparticles

Content Provider	Scilit
Author	Lai-Kwan, Chau Chang, Huan-Tsung
Copyright Year	2012
Description	The chapter reviews recent developments in the application of noble metal nanoparticles (NPs) to laser desorption/ionization mass spectrometry (LDI-MS), secondary ion MS (SIMS), and inductively coupled plasma MS (ICP-MS). Metal NPs as matrices in LDI-MS enable the selective and sensitive detection of biomolecules such as proteins, peptides, aminothiols, drugs, and carbohydrates. Metal NPs act as both signal enhancers and target concentrators in SIMS when they are attached to a well-controlled surface such as self-assembled monolayers. ICP-MS is well suited to determine the concentration of metal NPs that have been conjugated to antibody. Besides, metal NPs are capable of serving as afϐinity and concentrating probes for target analytes prior to LDI-MS. A table summarizes the applications of metal NPs to the analysis of a variety of analytes in LDI-MS. Book Name: From Bioimaging to Biosensors
Related Links	https://content.taylorfrancis.com/books/download?dac=C2012-0-00006-5&isbn=9780429088537&doi=10.1201/b13162-16&format=pdf
Ending Page	314
Page Count	32
Starting Page	283
DOI	10.1201/b13162-16
Language	English
Publisher	Informa UK Limited
Publisher Date	2012-10-26
Access Restriction	Open
Subject Keyword	Book Name: From Bioimaging To Biosensors Physical Chemistry Antibody Proteins Icp Sims Ldi Noble Metal Nps
Content Type	Text
Resource Type	Chapter

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