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Inhibition of microsomal lipid peroxidation by α-tocopherol and α-tocopherol acetate
| Content Provider | Scilit |
|---|---|
| Author | Flecha, B. S. Gonzalez Repetto, M. Evelson, P. Boveris, A. |
| Copyright Year | 1991 |
| Description | 1. The antioxidant effects of alpha-tocopherol and alpha-tocopherol acetate were assayed for the (a) oxygen uptake, (b) chemiluminescence and (c) malondialdehyde formation, of tert-butyl hydroperoxide-supplemented rat liver microsomes. 2. Oxygen uptake was inhibited 60% by both alpha-tocopherol and alpha-tocopherol acetate with the half-maximal effect at 5 nmol tocopherol/mg protein. Chemiluminescence and malondialdehyde formation were equally inhibited 35% by both tocopherols with half-maximal effects at 2 nmol tocopherol/mg protein. 3. The rate of O2 uptake by tocopherol-supplemented microsomes was dependent on O2 concentration. A 60% inhibition by 5 nmol tocopherol/mg protein at 0.2 mM O2 is decreased to 5% inhibition at 0.6 mM O2. 4. The inhibition of O2 uptake, chemiluminescence and malondialdehyde formation indicate that both alpha-tocopherol and alpha-tocopherol acetate have similar effects as free radical traps in the hydrophobic domain of biomembranes. The different inhibition observed at different O2 concentrations indicate competition between vitamin E and O2 by unoxygenated lipid radicals. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/00498259109039541 |
| Ending Page | 1022 |
| Page Count | 10 |
| Starting Page | 1013 |
| ISSN | 00498254 |
| e-ISSN | 13665928 |
| DOI | 10.3109/00498259109039541 |
| Journal | Xenobiotica |
| Issue Number | 8 |
| Volume Number | 21 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1991-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Xenobiotica Food Science and Technology Protein Alpha Tocopherol Acetate Alpha Tocopherol and Alpha Tocopherol |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Biochemistry Toxicology Pharmacology |
