NDLI: The metabolism of 9-methylanthracene by rat-liver microsomal preparations

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The metabolism of 9-methylanthracene by rat-liver microsomal preparations

Content Provider	Scilit
Author	Lamparczyk, H. S. McKay, S. Farmer, P. B. Cary, P. D. Grover, P. L. Sims, P.
Copyright Year	1986
Description	Journal: Xenobiotica The metabolism of 9-methylanthracene by liver microsomal preparations from 3-methylcholanthrene-treated rats was examined. The principal metabolites identified were 9-hydroxymethylanthracene, the 1,2- and 3,4-dihydrodiols of the parent hydrocarbon and the 3,4-dihydrodiol of the 9-hydroxymethyl derivative. A small amount of a product that appeared to be a phenolic derivative of the hydrocarbon was also formed. The structures of the major metabolites were confirmed by u.v., n.m.r., and mass-spectral analysis and, wherever possible, by direct comparison of their chromatographic properties with those of the authentic compounds. 9-Hydroxymethylanthracene was further metabolized by rat-liver microsomal preparations to the 3,4-dihydrodiol but not to the related 1,2-dihydrodiol.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/00498258609043535
Ending Page	333
Page Count	9
Starting Page	325
ISSN	00498254
e-ISSN	13665928
DOI	10.3109/00498258609043535
Journal	Xenobiotica
Issue Number	4
Volume Number	16
Language	English
Publisher	Informa UK Limited
Publisher Date	1986-01-01
Access Restriction	Open
Subject Keyword	Journal: Xenobiotica Legal Medicine Methylanthracene Rat Liver Microsomal Liver Microsomal Preparations
Content Type	Text
Subject	Health, Toxicology and Mutagenesis Medicine Biochemistry Toxicology Pharmacology

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