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Relationship between viral load and self-report measures of medication adherence among youth with perinatal HIV infection.
| Content Provider | Scilit |
|---|---|
| Author | Usitalo, Ann Leister, Erin Tassiopoulos, Katherine Allison, Susannah Malee, Kathleen Paul, Mary E. Smith, Renee Dyke, Russell B. Van Seage, George R. Mellins, Claude A. |
| Copyright Year | 2013 |
| Description | Poor adherence to antiretroviral therapy (ART) contributes to disease progression and emergence of drug-resistant HIV in youth with perinatally acquired HIV infection (PHIV +), necessitating reliable measures of adherence. Although electronic monitoring devices have often been considered the gold-standard assessment in HIV research, they are costly, can overestimate nonadherence and are not practical for routine care. Thus, the development of valid, easily administered self-report adherence measures is crucial for adherence monitoring. PHIV+youth aged 7–16 (n = 289) and their caregivers, enrolled in a multisite cohort study, were interviewed to assess several reported indicators of adherence. HIV-1 RNA viral load (VL) was dichotomized into >/≤400 copies/mL. Lower adherence was significantly associated with VL >400 copies/mL across most indicators, including ≥1 missed dose in past seven days [youth report: OR = 2.78 (95% CI, 1.46–5.27)]. Caregiver and combined youth/caregiver reports yielded similar results. Within-rater agreement between various adherence indicators was high for both youth and caregivers. Inter-rater agreement on adherence was moderate across most indicators. Age ≥13 years and living with biological mother or relative were associated with VL >400 copies/mL. Findings support the validity of caregiver and youth adherence reports and identify youth at risk of poor adherence. |
| Related Links | http://europepmc.org/articles/pmc4190051?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190051/pdf |
| ISSN | 09540121 |
| e-ISSN | 13600451 |
| DOI | 10.1080/09540121.2013.802280 |
| Journal | AIDS Care |
| Issue Number | 1 |
| Volume Number | 26 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2013-06-14 |
| Access Restriction | Open |
| Subject Keyword | Journal: Aids Care Clinical Psychology Hiv Adherence Antiretroviral Pediatric |
| Content Type | Text |
| Resource Type | Article |
| Subject | Public Health, Environmental and Occupational Health Health (social science) Social Psychology |
