NDLI: RELATIONSHIP BETWEEN VIRAL LOAD AND SELF-REPORT MEASURES OF MEDICATION ADHERENCE AMONG YOUTH WITH PERINATAL HIV INFECTION

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RELATIONSHIP BETWEEN VIRAL LOAD AND SELF-REPORT MEASURES OF MEDICATION ADHERENCE AMONG YOUTH WITH PERINATAL HIV INFECTION

Content Provider	PubMed Central
Author	Ann, Usitalo Leister, Erin Katherine, Tassiopoulos Allison, Susannah Kathleen, Malee Paul, Mary E. Smith, Renee Dyke, Russell B. Van Seage, George R. Mellins, Claude A.
Abstract	Poor adherence to antiretroviral therapy (ART) contributes to disease progression and emergence of drug-resistant HIV in youth with perinatally acquired HIV infection (PHIV+), necessitating reliable measures of adherence. Although electronic monitoring devices have often been considered the gold standard assessment in HIV research, they are costly, can overestimate non-adherence and are not practical for routine care. Thus, development of valid, easily administered self-report adherence measures is crucial for adherence monitoring. PHIV+ youth aged 7–16 (n=289) and their caregivers, enrolled in a multisite cohort study, were interviewed to assess several reported indicators of adherence. HIV-1 RNA viral load (VL) was dichotomized into >/≤400 copies/ml. Lower adherence was significantly associated with VL >400 copies/ml across most indicators, including ≥ 1 missed dose in past 7 days [youth report OR=2.78 (95% CI 1.46–5.27)]. Caregiver and combined youth/caregiver reports yielded similar results. Within-rater agreement between various adherence indicators was high for both youth and caregivers. Inter-rater agreement on adherence was moderate across most indicators. Age ≥13 years and living with biological mother or relative were associated with VL > 400 copies/ml. Findings support the validity of caregiver and youth adherence reports and identify youth at risk of poor adherence.
Related Links	http://dx.doi.org/10.1080/09540121.2013.802280
Ending Page	115
Page Count	9
Starting Page	107
File Format	PDF
ISSN	09540121
e-ISSN	13600451
Journal	AIDS care
Issue Number	1
Volume Number	26
Language	English
Publisher Date	2014-01-02
Access Restriction	Open
Subject Keyword	Public Health, Environmental and Occupational Health Health(social science) Social Psychology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health Health (social science) Social Psychology

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