NDLI: Treatment with Thymosin Alpha-1 Increases Fertilizing Capacity of Sperm of Infertile Men: A Multicenter Trial

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Treatment with Thymosin Alpha-1 Increases Fertilizing Capacity of Sperm of Infertile Men: A Multicenter Trial

Content Provider	Scilit
Author	Naz, R. K. Menge, A. C. Sacco, A.
Copyright Year	1995
Description	Thymosin alpha-1 (Tal) significantly enhances the fertilizability of sperm from fertile men by increasing capacitation and/or acrosome reaction. The present study was conducted to investigate the effect of Tal on fertilizing capacity of sperm of infertile men using the sperm penetration assay (SPA) in a multicenter clinical trial. Tal significantly (p =. 0006 to <. 0001) increased (31 to 45%) fertilizing capacity of sperm of 76% (50/68) of infertile men as defined by the sperm penetration index in SPA. The enhancing effect of Tal and the degree of enhancement depended on the Tal concentration in the seminal plasma, since these parameters showed a significant intercorrelation (r =. 65 to. 74, p =. 039 to. 01). It would appear that Tal may have clinical application in the diagnosis and treatment of male infertility especially mediated through defective sperm function.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/01485019508987866
Ending Page	154
Page Count	6
Starting Page	149
ISSN	01485016
e-ISSN	15210375
DOI	10.3109/01485019508987866
Journal	Archives of andrology
Issue Number	2
Volume Number	35
Language	English
Publisher	Informa UK Limited
Publisher Date	1995-01-01
Access Restriction	Open
Subject Keyword	Journal: Archives of Andrology Andrology Sperm Infertile Men Treatment Thymosin Alpha Fertilizing Capacity Multicenter Trial
Content Type	Text
Resource Type	Article
Subject	Endocrinology

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