NDLI: Fast Neutron Radiation Therapy: Results of phase III randomized trials in head and neck, lung, and prostate cancers

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Fast Neutron Radiation Therapy: Results of phase III randomized trials in head and neck, lung, and prostate cancers

Content Provider	Scilit
Author	Koh, Wui-Jin Griffin, Thomas W. Laramore, George E. Stelzer, Keith J. Russell, Kenneth J.
Copyright Year	1994
Description	The results of phase III trials comparing neutrons to photons for head and neck squamous cell cancers, non-small cell lung cancers, and prostate adenocarcinomas are reviewed, with emphasis given to the most recent U.S. National Cancer Institute sponsored randomized clinical studies in which fast neutrons were delivered using modern, hospital-based, high-energy, isocentric-capable cyclotrons. In locally advanced squamous cell head and neck cancers, neutrons showed no convincing advantage over photons. Fast neutron radiotherapy may have provided a therapeutic benefit in selected patients with inoperable non-small cell lung cancers. For locally advanced prostate adenocarcinomas, neutron therapy resulted in significantly superior clinical and histological loco-regional tumor control, which may translate to improved survival with additional follow-up. In general, severe late complications were more frequent with neutrons, especially in patients treated on older physics laboratory-based equipment. Even with modern state-of-the-art neutron generators, careful beam collimation and treatment planning are required to minimize side effects.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/02841869409098420
Ending Page	298
Page Count	6
Starting Page	293
ISSN	0284186X
e-ISSN	1651226X
DOI	10.3109/02841869409098420
Journal	Acta Oncologica
Issue Number	3
Volume Number	33
Language	English
Publisher	Informa UK Limited
Publisher Date	1994-01-01
Access Restriction	Open
Subject Keyword	Journal: Acta Oncologica Radiology, Nuclear Medicine and Imaging Radiation Therapy Randomized Trial
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Hematology Oncology

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