NDLI: Identification of novel Syk-independent functional roles of FcγRIIa in platelet outside-in signaling using transgenic mice expressing human FcγRIIa

Please wait, while we are loading the content...

Identification of novel Syk-independent functional roles of FcγRIIa in platelet outside-in signaling using transgenic mice expressing human FcγRIIa

Content Provider	Scilit
Author	Buitrago, Lorena Manne, Bhanu Kanth Andre, Pierrette McKenzie, Steven Kunapuli, Satya
Copyright Year	2016
Description	Platelet outside-in signaling regulates important morphological changes such as cell spreading and retraction. A role for FcγRIIa in outside-in signaling has been recently described. Using murine platelets expressing human transgenic FcγRIIa we expand the evidence for the role of human FcγRIIa in platelet outside-in signaling. Transgenic murine platelets spread more on fibrinogen when compared to WT platelets. Importantly, the role of FcγRIIa in clot retraction was independent of its association with Syk kinase as evidence by the kinetics of retraction with the Syk inhibitor OXSI-2. The enhanced platelet spreading in transgenic mice is reflected in increased Syk phosphorylation and activity as downstream targets PLCγ2 and c-Cbl Y774. Nonetheless, the WT counterparts exhibit phosphorylation of Syk and PLCγ2 suggesting that murine platelets have evolved an alternative FcγRIIa-independent outside-in signaling mechanism.
Related Links	http://europepmc.org/articles/pmc4975857?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975857/pdf https://www.tandfonline.com/doi/pdf/10.3109/09537104.2015.1119813
Ending Page	490
Page Count	3
Starting Page	488
ISSN	09537104
e-ISSN	13691635
DOI	10.3109/09537104.2015.1119813
Journal	Platelets
Issue Number	5
Volume Number	27
Language	English
Publisher	Informa UK Limited
Publisher Date	2016-01-25
Access Restriction	Open
Subject Keyword	Journal: Platelets Hematology Research and Experimental Medicine Phosphorylation Syk Fcγriia Murine Platelets Transgenic Mice Plcγ2 Functional
Content Type	Text
Subject	Hematology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Anti–miR-148a regulates platelet FcγRIIA signaling and decreases thrombosis in vivo in mice

Fruitflow inhibits platelet function by suppressing Akt/GSK3β, Syk/PLCγ2 and p38 MAPK phosphorylation in collagen-stimulated platelets

Integrin α2β1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCγ2

Identification of FcγRIIa as the ITAM-bearing receptor mediating αIIbβ3 outside-in integrin signaling in human platelets

A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2

Identification of FcγRIIa as the ITAM-bearing receptor mediating αIIbβ3 outside-in integrin signaling in human platelets

Critical role of Src-Syk-PLCγ2 signaling in megakaryocyte migration and thrombopoiesis

Go6976 abrogates GPVI-mediated platelet functional responses in human platelets through inhibition of Syk

P2X1 Receptors Amplify FcγRIIa-Induced Ca2+ Increases and Functional Responses in Human Platelets.

Identification of novel Syk-independent functional roles of FcγRIIa in platelet outside-in signaling using transgenic mice expressing human FcγRIIa

Similar Documents

Anti–miR-148a regulates platelet FcγRIIA signaling and decreases thrombosis in vivo in mice

Fruitflow inhibits platelet function by suppressing Akt/GSK3β, Syk/PLCγ2 and p38 MAPK phosphorylation in collagen-stimulated platelets

Integrin α2β1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCγ2

Identification of FcγRIIa as the ITAM-bearing receptor mediating αIIbβ3 outside-in integrin signaling in human platelets

A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2

Identification of FcγRIIa as the ITAM-bearing receptor mediating αIIbβ3 outside-in integrin signaling in human platelets

Critical role of Src-Syk-PLCγ2 signaling in megakaryocyte migration and thrombopoiesis

Go6976 abrogates GPVI-mediated platelet functional responses in human platelets through inhibition of Syk

P2X1 Receptors Amplify FcγRIIa-Induced Ca2+ Increases and Functional Responses in Human Platelets.

Identification of novel Syk-independent functional roles of FcγRIIa in platelet outside-in signaling using transgenic mice expressing human FcγRIIa