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Umbilical cord blood CD45+/CD34+cells coexpression in preterm and full-term neonates: a pilot study
| Content Provider | Scilit |
|---|---|
| Author | Hassanein, Sahar M. A. Amer, Hanaa A. Shehab, Abeer A. Hellal, Mahmoud M. K. H. |
| Copyright Year | 2010 |
| Description | Human umbilical cord blood (hUCB) is rich in stem cells. The CD45(+)/CD34(+) coexpression in hUCB is a marker of hemopoietic progenitor cells. The objective of this study is to compare the coexpression of hUCB CD45(+)/CD34(+) cells in preterm (PT) and full-term (FT) neonates. We studied the coexpression of hUCB CD45(+)/CD34(+) cells in PT and FT neonates. The study included 25 PT (29-36 weeks gestation) and 25 FT (37-41) neonates delivered at Ain Shams University, Maternity Hospital. Absolute mononuclear layer cord blood CD45(+)/CD34(+) cell count were measured by flow cytometry. Morbidity was assessed for 12 of the studied 25 PT infants, using Morbidity Assessment Index for Newborns score. The absolute CD45(+)/CD34(+) count did not differ between PT and FT infants: Z = -0.485, p = 0.63. There was no correlation between absolute cell count and GA (r = 0.013, p = 0.9) for all 50 neonates. Mode of delivery did not affect the absolute count in the PT infants: Z = -0.6, p = 0.57. There was no correlation between the degree of morbidity and absolute cell count in PT neonates; r = 0.13, p = 0.69. The absolute cell count is not affected by gestational age and did not relate to morbidity scores in the studied PT infants. Further, wide-scale work will be needed to study CD45(+)/CD34(+) count in hUCB in sick PT neonates. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/14767058.2010.482606 |
| Ending Page | 233 |
| Page Count | 5 |
| Starting Page | 229 |
| ISSN | 14767058 |
| e-ISSN | 14764954 |
| DOI | 10.3109/14767058.2010.482606 |
| Journal | The Journal of Maternal-Fetal & Neonatal Medicine |
| Issue Number | 2 |
| Volume Number | 24 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2010-06-14 |
| Access Restriction | Open |
| Subject Keyword | Journal: The Journal of Maternal-fetal & Neonatal Medicine Pediatrics and Child Health Cd45 Cd34 Neonates Coexpression Hucb Umbilical Infants Morbidity Absolute |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pediatrics, Perinatology and Child Health Obstetrics and Gynecology |
