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An Evaluation of Croscarmellose as a Tablet Disintegrant in Direct Compression Systems
| Content Provider | Scilit |
|---|---|
| Author | Gorman, E. A. Rhodes, C. T. Rudnic, E. M. |
| Copyright Year | 1982 |
| Description | The disintegrant actions of croscarmellose type A (Ac-Di-Sol, FMC Corp.) and croscarmellose type B (CLD-2, Buckeye Cellulose Corp.) have been compared to that of corn starch in direct compression tablets in which microcrystalline cellulose (Avicel PH101, FMC Corp.) was the matrix. Two types of formulations were examined using either pyridoxine or hydrochlorothiazide as drug. The data clearly shows that both forns of croscarmellose are markedly superior to corn starch and are active at quite low concentrations. The CLD-2 may promote more rapid dissolution in some systems than Ac-Di-Sol. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/03639048209022108 |
| Ending Page | 410 |
| Page Count | 14 |
| Starting Page | 397 |
| ISSN | 03639045 |
| e-ISSN | 15205762 |
| DOI | 10.3109/03639048209022108 |
| Journal | Drug Development and Industrial Pharmacy |
| Issue Number | 3 |
| Volume Number | 8 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1982-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Drug Development and Industrial Pharmacy Integrative and Complementary Medicine Paper and Wood Tablet Disintegrant Direct Compression Compression Systems Evaluation of Croscarmellose |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science |
