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Ethnic diversity in infant gut microbiota is apparent before the introduction of complementary diets
| Content Provider | Scilit |
|---|---|
| Author | Xu, Jia Lawley, Blair Wong, Gerard Otal, Anna Chen, Li Ying, Toh Jia Lin, Xinyi Pang, Wei Wei Yap, Fabian Chong, Yap-Seng Gluckman, Peter D. Lee, Yung Seng Chong, Mary Foong-Fong Tannock, Gerald W. Karnani, Neerja |
| Copyright Year | 2020 |
| Description | The human gut microbiota develops soon after birth and can acquire inter-individual variation upon exposure to intrinsic and environmental cues. However, inter-individual variation has not been comprehensively assessed in a multi-ethnic study. We studied a longitudinal birth cohort of 106 infants of three Asian ethnicities (Chinese, Malay, and Indian) that resided in the same geographical location (Singapore). Specific and temporal influences of ethnicity, mode of delivery, breastfeeding status, gestational age, birthweight, gender, and maternal education on the development of the gut microbiota in the first 2 years of life were studied. Mode of delivery, breastfeeding status, and ethnicity were identified as the main factors influencing the compositional development of the gut microbiota. Effects of delivery mode and breastfeeding status lasted until 6M and 3M, respectively, with the primary impact on the diversity and temporal colonization of the genera Bacteroides and Bifidobacterium. The effect of ethnicity was apparent at 3M post-birth, even before the introduction of weaning (complementary) foods, and remained significant after adjusting for delivery mode and breastfeeding status. Ethnic influences remained significant until 12M in the Indian and Chinese infants. The microbiota of Indian infants was characterized by higher abundances of Bifidobacterium and Lactobacillus, while Chinese infants had higher abundances of Bacteroides and Akkermansia. These findings provide a detailed insight into the specific and temporal influences of early life factors and ethnicity in the development of the human gut microbiota. Trial Registration: Clinicaltrials.gov registration no. NCT01174875. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524347/pdf |
| Ending Page | 1373 |
| Page Count | 12 |
| Starting Page | 1362 |
| ISSN | 19490976 |
| e-ISSN | 19490984 |
| DOI | 10.1080/19490976.2020.1756150 |
| Journal | Gut Microbes |
| Issue Number | 5 |
| Volume Number | 11 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2020-09-02 |
| Access Restriction | Open |
| Subject Keyword | Journal: Gut Microbes Pediatrics and Child Health Early Gut Microbiota Ethnicity Delivery Mode Breastfeeding Birth Cohort |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Gastroenterology Microbiology Microbiology (medical) |
