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Four Years of Clinical Experience with Naproxen–And Objective Methods of Evaluation
| Content Provider | Scilit |
|---|---|
| Author | Katona, G. |
| Copyright Year | 1973 |
| Abstract | There has been opportunity to carry out very large and extended clinical studies with naproxen. These studies have extended over a period of nearly four years. This work began with the original pilot studies in 21 patients having rheumatoid arthritis. Subsequent to that some 300 patients have been observed in a variety of special studies, most of which were conducted using double-blind methodology. These included comparisons against placebo in rheumatoid arthritis, comparison against aspirin in rheumatoid arthritis, comparison with indomethacin in degenerative joint disease, studies of extra-articular rheumatism and assorted pain states, and evaluation of the corticoid-sparing effect of naproxen in patients with rheumatoid arthritis. Many of the patients from these special studies were subsequently continued in open trials for long term assessment of efficacy and tolerance. Additional patients were recruited directly into long term studies. The total number of patients seen for extended periods is 415. Some of these have been under naproxen therapy continuously for periods up to 46 months. This long term population has included 271 patients with rheumatoid arthritis, 69 with degenerative joint disease, 10 with gout, and 65 with extra-articular rheumatism or various pain states. In addition to the clinical evaluations we have carried out objective studies in a further 15 subjects. These objective studies have included direct visualization by means of arthroscopy, joint fluid aspiration and enzymologic study, histopathologic examination of the synovial membrane, and joint scanning using technetium 99. The various objective studies have served to provide clear confirmation of the clinical experience. It is apparent that naproxen is both effective and well tolerated as an analgesic and anti-inflammatory agent. Our considerable clinical experience with naproxen has demonstrated relevant antirheumatic activity and outstanding tolerance. Using some objective methods to detect the actual anti-inflammatory effect, confirmation of the clinical findings was obtained and additional important observations were made that could be related to the possible mechanism of action of naproxen. Noteworthy was a remarkable decrease in the concentration of some lysosomic enzymes (acid phosphatase and cathepsin) as well as important changes in synovial membrane histopathological pattern after therapy with naproxen in a number of patients. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/03009747309097107 |
| Ending Page | 108 |
| Page Count | 8 |
| Starting Page | 101 |
| ISSN | 03009742 |
| e-ISSN | 15027732 |
| DOI | 10.3109/03009747309097107 |
| Journal | Scandinavian Journal of Rheumatology |
| Issue Number | sup2 |
| Volume Number | 2 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1973-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Scandinavian Journal of Rheumatology Orthopedics Four Years Clinical Experience Objective Methods Evaluation Years of Clinical Experience with Naproxen |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology Rheumatology |
