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Heparin and Fibrinolysis - Comparison of Subcutaneous Administration of Unfractionated and Low Molecular Weight Heparin
| Content Provider | Scilit |
|---|---|
| Author | Eriksson, E. Christenson, B. Stigendal, L. Risberg, B. |
| Editor | Wollter, I. M. |
| Copyright Year | 1988 |
| Description | The effects on the fibrinolytic system after a single s.c. bolus injection (at 9 a.m.) of either 5000 IU conventional heparin or 5000 anti-Xa U of a fractionated low molecular weight heparin (Fragmin, KabiVitrum, Sweden) were investigated in 9 healthy volunteers. The effects were compared to those of an injection of normal saline in 6 volunteers. Samples for biochemical analyses were taken regularily during 6 hours after drug or placebo administration. In the coagulation system the following parameters were measured: Activated partial thromboplastin time (APTT), anti- Xa activity, thrombin time and fibrinogen. The fibrinolytic system was monitored by analysing: plasminogen, $ɑ_{2}$-antiplasmin, fibrinogen) degradation products (FDP), euglobulin clot lysis time (ECLT), tissue plasminogen activator (t-PA) activity, t-PA antigen and plasminogen activator inhibitor (PAI) activity. Injection of the 2 drugs was followed by elevations in APTT and anti-Xa activity, and were more pronounced for Fragmin than heparin. The fibrinolytic system exhibited a diurnal variation with decreasing PAI activity and increasing t-PA activity during the day. Volunteers receiving normal saline (placebo) showed a similar pattern. The results were unrelated to heparin. It is concluded from this study that neither heparin nor Fragmin had any significant effect on the fibrinolytic parameters when measured after a single s.c. bolus injection since the observed variations were within the diurnal range. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0038-1642772.pdf |
| Ending Page | 288 |
| Page Count | 5 |
| Starting Page | 284 |
| ISSN | 2567689X |
| DOI | 10.1055/s-0038-1642772 |
| Journal | Thrombosis and Haemostasis |
| Issue Number | 02 |
| Volume Number | 59 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 1988-04-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Thrombosis and Haemostasis Unfractionated Herpin Low Molecular Weight Heparin Tissue Plasminogen Activator |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology |
