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Contribution of a New, Rapid, Individual and Quantitative Automated D-Dimer ELISA to Exclude Pulmonary Embolism
| Content Provider | Scilit |
|---|---|
| Author | de Moerloose, Philippe Desmarais, Sylvie Bounameaux, Henri Reber, Guido Perrier, Arnaud Dupuy, Georges Pittet, Jean-Louis |
| Copyright Year | 1996 |
| Description | Summary: The performance of a new automated ELISA for a rapid, individual and quantitative measurement of plasma D-dimer (VIDAS D-dimer) has been evaluated. First, a study of 100 patients was performed in order to choose the best couple of antibodies in comparison with an already clinically validated ELISA. Then the results were certified in a prospective study including 195 consecutive patients suspected of pulmonary embolism (PE). For a cut-off level of 500 ng/ml VIDAS D-dimer showed a sensitivity of 100% (95% confidence interval 92-100), a specificity of 37.6%, a negative predictive value of 100% (95% CI 93.3-100) and a positive predictive value of 33.1%. During a 6 months’ follow-up no patient (95% CI 0-6.4) with D-dimer <500 ng/ml presented a new suspicion of venous thromboembolic disease. These results suggest that this rapid and single-dose ELISA provides a very useful tool for the clinician to exclude on a day-to-day basis the diagnosis of PE. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0038-1650213.pdf |
| Ending Page | 013 |
| Page Count | 3 |
| Starting Page | 011 |
| ISSN | 2567689X |
| DOI | 10.1055/s-0038-1650213 |
| Journal | Thrombosis and Haemostasis |
| Issue Number | 01 |
| Volume Number | 75 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 1996-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Thrombosis and Haemostasis Infectious Diseases |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology |
