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Prognostic value of D-dimer in patients with pulmonary embolism
| Content Provider | Scilit |
|---|---|
| Author | Roy, Pierre-Marie Guy, Meyer Cornuz, Jacques Sanchez, Olivier Perrier, Arnaud Aujesky, Drahomir |
| Copyright Year | 2006 |
| Description | Summary D-dimer levels appear to be associated with the extent of the thromboembolic burden in patients with pulmonary embolism (PE).We therefore hypothesized that D-dimer levels at admission would be associated with prospective risk of mortality in patients with PE. We used data from 366 patients diagnosed with PE at four hospital emergency departments. A highly sensitive D-dimer test was prospectively performed at admission. The outcome was overall mortality within three months. We divided patients into quartiles on the basis of their D-dimer levels and compared mortality rates by quartile. We estimated sensitivity, specificity, and predictive values for mortality in the first and fourth quartile. Overall mortality was 5.2%. Patients who died had higher median D-dimer levels than patients who survived (4578 versus 2946 µg/l; P=0.005). Mortality increased with increasing D-dimer levels, rising from 1.1% in the first quartile (5500 µg/l) (P=0.049). Sensitivity, specificity, and positive and negative predictive values of D-dimer levels <1500 µg/l to predict mortality were 95%, 26%, 7%, and 99%, respectively. Patients with PE who have D-dimer levels below 1500 µg/l havea very low mortality. Further studies must assess whether D-dimer, alone or combined with other prognostic instruments for PE, can be used to identify low-risk patients with PE who are potential candidates for outpatient treatment or an abbreviated hospital stay. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1160/TH06-07-0416.pdf |
| Ending Page | 482 |
| Page Count | 5 |
| Starting Page | 478 |
| ISSN | 2567689X |
| DOI | 10.1160/th06-07-0416 |
| Journal | Thrombosis and Haemostasis |
| Issue Number | 10 |
| Volume Number | 96 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2006-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Thrombosis and Haemostasis Respiratory System Dimer Levels Values of D Dimer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology |
