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The Effect of Diabetes on Leucine and Fucose Incorporation into PNS Myelin Proteins
| Content Provider | Scilit |
|---|---|
| Author | O'Connor, B. Baughman, S. Felten, S. Lee, W. Moore, S. Peterson, R. |
| Copyright Year | 1981 |
| Description | Peripheral neuropathy is a common complication associated with diabetes mellitus. Segmental demyelination and other pathological changes frequently accompany loss of sensory and motor nerve function. Morphological changes seen in diabetic nerve myelin may be a result of altered Schwann cell metabolism under hyperglycemic conditions. Using both alloxan and streptozotocin - induced diabetic rats of 2, 4 and 8 months duration of diabetes, metabolic changes in isolated sciatic nerve myelin were assessed using a double-label in vitro incubation system. Incorporation of$ ^{3}$H-fucose and $1-^{14}$C-leucine into myelin was determined per microgram protein. Specific activities of incorporated protein precursors were compared as a ratio of fucose to leucine. Using the Newman-Kuels test for multiple comparisons, statistically significant increases were found in the incorporation ratios of diabetic rats at 2 and 4 months of diabetes when tested against agematched controls. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-1019259.pdf |
| Ending Page | 335 |
| Page Count | 5 |
| Starting Page | 331 |
| ISSN | 00185043 |
| e-ISSN | 14394286 |
| DOI | 10.1055/s-2007-1019259 |
| Journal | Hormone and Metabolic Research |
| Issue Number | 06 |
| Volume Number | 13 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 1981-06-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Hormone and Metabolic Research Cell Tissue Engineering Key-words: Streptozotocin Diabetes Alloxan Diabetes Protein Incorporation Glycoprotein Incorporation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Endocrinology, Diabetes and Metabolism Biochemistry Clinical Biochemistry Endocrinology |
