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Characterisation of a Monoclonal Antibody to von Willebrand Factor as a Potent Inhibitor of Ristocetin-Mediated Platelet Interaction and Platelet Adhesion
| Content Provider | Scilit |
|---|---|
| Author | Jorieux, Sylvie de Romeuf, Christophe Samor, Bruno Goudemand, Maurice Mazurier, Claudine |
| Copyright Year | 1987 |
| Description | We studied a murine monoclonal antibody (211 A6) to von Willebrand factor (vWF) with a view to investigating structure-relationship. of plasma vWF. The specificity of this antibody has been substantiated by ELISA tests and indirect immunofluorescence. It reacts with purified vWF, normal plasma but not with plasma or platelets from a severe von Willebrand’s disease patient. Monoclonal antibody 211 A6 is a potent inhibitor of ristocetin-induced platelet aggregation. The$ ^{125}$I-FVIII/vWF binding to platelets in presence of ristocetin is totally inhibited by low 211 A6 concentrations. Thrombin-induced binding of vWF to platelets is not affected by 211 A6. The ability of this antibody to inhibit platelet adhesion to subendothelium and to collagen was investigated with a perfusion model. The complete inhibition of platelet adhesion by 211 A6 questions the similarity or the interrelationship in vWF domains involved in ristocetin-induced platelet functions and platelet adhesion. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0038-1651116.pdf |
| Ending Page | 282 |
| Page Count | 5 |
| Starting Page | 278 |
| ISSN | 2567689X |
| DOI | 10.1055/s-0038-1651116 |
| Journal | Thrombosis and Haemostasis |
| Issue Number | 03 |
| Volume Number | 57 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 1987-06-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Thrombosis and Haemostasis Monoclonal Antibody Von Willebrand Factor Ristocetin Cofactor Platelet Adhesion |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology |
