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C 2-Symmetric Chiral Bis(thiazoline) and Bis(oxazoline) Ligands and their Application in the Catalytic Asymmetric Allylic Alkylation
| Content Provider | Scilit |
|---|---|
| Author | Du, Da-Ming Fu, Bin Xia, Qing |
| Copyright Year | 2004 |
| Description | A series of novel C$ _{2}$-symmetric bis(thiazoline) ligands with dibenzo[a,c]cycloheptadiene backbone as the substituent on the thiazoline ring were synthesized using the simple reagent phosphorus pentasulfide, and their application in catalytic allylic alkylation was investigated by comparison with the corresponding bis(oxazolines). Palladium-bis(oxazoline) complexes furnished good enantioselectivity (up to 87% ee), while bis(thiazolines) only gave up to moderate enantioselectivity (56% ee) with $CH_{2}Cl_{2}$ as solvent. Preliminary explanation of the catalysis mechanism is given for the difference of two types of Pd(0)-ligand complexes. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2004-815917.pdf |
| Ending Page | 226 |
| Page Count | 6 |
| Starting Page | 221 |
| ISSN | 00397881 |
| e-ISSN | 1437210X |
| DOI | 10.1055/s-2004-815917 |
| Journal | Synthesis |
| Issue Number | 2 |
| Volume Number | 2004 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2004-01-13 |
| Access Restriction | Open |
| Subject Keyword | Journal: Synthesis Organic Chemistry Allylic Alkylation Asymmetric Catalysis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Catalysis |
