NDLI: A Novel Chiral Base Mediated Glutarimide Desymmetrisation: Application to the Asymmetric Synthesis of (-)-Paroxetine

Content Provider	Scilit
Author	Simpkins, Nigel S. Greenhalgh, Daniel A.
Copyright Year	2002
Description	The asymmetric desymmetrisation of certain 4-aryl substituted glutarimides has been accomplished with high levels of selectivity (up to 97% ee) by enolisation with a chiral bis-lithium amide base. The selectivity of the reaction is shown to be the result of asymmetric enolisation, followed by a kinetic resolution. One of the chiral imides synthesised was converted into the selective seratonin reuptake inhibitor (-)-paroxetine.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2002-35588.pdf
Ending Page	2076
Page Count	3
Starting Page	2074
ISSN	09365214
e-ISSN	14372096
DOI	10.1055/s-2002-35588
Journal	Synlett
Issue Number	12
Volume Number	2002
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2002-11-20
Access Restriction	Open
Subject Keyword	Journal: Synlett Organic Chemistry Chiral Lithium Amide Kinetic Resolution
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry

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A Novel Chiral Base Mediated Glutarimide Desymmetrisation: Application to the Asymmetric Synthesis of (-)-Paroxetine