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Evidence for Early Impairment of Glucagon-Like Peptide 1-Induced Insulin Secretion in Human Type 2 (Non Insulin-Dependent) Diabetes
| Content Provider | Scilit |
|---|---|
| Author | Lugari, R. Ugolotti, D. Finardi, L. Barilli, A. Ognibene, C. Luciani, A. Zandomeneghi, R. Gnudi, A. |
| Editor | Cas, A. Dei |
| Copyright Year | 2002 |
| Description | To investigate a possible role of an enteroinsular axis involvement in the pathogenesis of type 2 diabetes, plasma glucagon-like peptide 1 (GLP-1) 7-36 amide response to nutrient ingestion was evaluated in type 2 diabetics affected by different degrees of β-cell dysfunction. Methods: 14 patients on oral hypoglycaemic treatment (group A: HbA1C = 8.1 ± 1.8 %) and 11 age-matched diabetic patients on diet only (group B: HbA1C = 6.4 ± 0.9) participated in the study. 10 healthy volunteers were studied as controls. In the postabsorptive state, a mixed meal (700 kCal) was administered to all subjects, and blood samples were regularly collected up to 180′ for plasma glucose, insulin, glucagon, and GLP-1 determination. Results: In the control group, the test meal induced a significant increase in plasma GLP-1 at 30′ and 60′ (p < 0.01); the peptide concentrations then returning toward basal levels. β-cell function estimation by HOMA score confirmed a more advanced involvement in group A than in group B (p < 0.01). In contrast, the insulin resistance degree showed a similar result in the two groups (HOMA-R). In group A, first-phase postprandial insulin secretion (0 - 60’) resulted, as expected, in being significantly reduced compared to healthy subjects (p < 0.001). In the same patients the mean fasting GLP-1 value was similar to controls, but the meal failed to increase plasma peptide levels, which even tended to decrease during the test (p < 0.01). In group B, food-mediated early insulin secretion was higher than in group A (p < 0.001), although significantly reduced when compared to controls (p < 0.01). Like group A, no GLP-1 response to food ingestion occurred in group B patients in spite of maintained basal peptide secretion. Whereas the test-meal did not significantly modify plasma glucagon levels in the control group, glucagon concentrations increased at 30’ and 60’ in both diabetic groups (p < 0.01). Conclusions: 1) The functional integrity of GLP-1 cells results as being seriously impaired even in the condition of mild diabetes; 2) the early peptide failure could contribute to the development of β-cell deterioration which characterizes overt type 2 diabetes. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2002-23199.pdf |
| Ending Page | 154 |
| Page Count | 5 |
| Starting Page | 150 |
| ISSN | 00185043 |
| e-ISSN | 14394286 |
| DOI | 10.1055/s-2002-23199 |
| Journal | Hormone and Metabolic Research |
| Issue Number | 03 |
| Volume Number | 34 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2002-03-26 |
| Access Restriction | Open |
| Subject Keyword | Journal: Hormone and Metabolic Research Endocrinology and Metabolism Enteroinsular Axis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Endocrinology, Diabetes and Metabolism Biochemistry Clinical Biochemistry Endocrinology |
