Loading...
Please wait, while we are loading the content...
Similar Documents
Glucagon-Like Peptide 1 and its Potential in the Treatment of Non-Insulin-Dependent Diabetes Mellitus
| Content Provider | Scilit |
|---|---|
| Author | Nauck, M. Holst, J. Willms, B. |
| Copyright Year | 1997 |
| Description | Studies examining small groups of type 2-(NIDDM) diabetic patients have shown the potential of glucagon-like peptide 1 (GLP-1) to normalize fasting hyperglycaemia. Patient characteristics determining the size of the effect have not been reported. Therefore, the results of four studies were analysed. Exogenous GLP-1 was administered i.v. or s.c. in 37 type 2-diabetic patients, age 60 ± 8 years; BMI 28.2 ± 5.3 $kg/m^{2}$; $HbA_{1c}$ 10.6 ± 1.6%; diabetes duration 10 ± 6 years, treatment with sulfonylureas, n = 33, metformin, n = 11, acarbose, n = 3. Results were analysed using repeated measures analysis of variance and multiple regression analysis. Exogenous GLP-1 lowered fasting plasma glucose within 4-5 h from 12.8 ± 2.5 to 5.3 ± 1.3 mmol/l (placebo: 12.8 ± 2.3 to 10.0 ± 2.2; p < 0.0001 for the interaction of treatment and time). Only fasting glycaemia (p = 0.0085) and the route (i.v. vs.s.c.; p = 0.05), but not gender, age, BMI, $HbA_{1c}$ diabetes duration, treatment with sulfonylureas, metformin or acarbose, were significant predictors of the plasma glucose concentrations reached after the administration of GLP-1 (variation: 3.4-8.5 mmol/l). In conclusion, GLP-1 is able to normalize plasma glucose in all type 2-diabetic patients studied. This analysis underlines the great therapeutic potential of GLP-1. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-979067.pdf |
| Ending Page | 416 |
| Page Count | 6 |
| Starting Page | 411 |
| ISSN | 00185043 |
| e-ISSN | 14394286 |
| DOI | 10.1055/s-2007-979067 |
| Journal | Hormone and Metabolic Research |
| Issue Number | 09 |
| Volume Number | 29 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 1997-09-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Hormone and Metabolic Research Endocrinology and Metabolism Glucagon-like Peptide-1 Type 2 Diabetes Gastric Emptying |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Endocrinology, Diabetes and Metabolism Biochemistry Clinical Biochemistry Endocrinology |
