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Large-scale Synthesis of GMP Grade N'-[2-(2-Thiophene)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea (HI-443), a New Anti-HIV Drug Candidate
| Content Provider | Scilit |
|---|---|
| Author | DuMez, Darin Venkatachalam, Taracad K. Uckun, Fatih M. |
| Copyright Year | 2007 |
| Description | The thiourea compound N'-[2-(2-thio-phene)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea (HI-443, CAS 258340-15-7), was found to be a potent anti-HIV agent with remarkable activity against nucleoside analog reverse transcriptase (NRT)-resis-tant, non-nucleoside analog reverse transcriptase (NNRT) -resistant, as well as multidrug-resistant HIV. Now the method of producing HI-443 under current Good Manufacturing Practice (cGMP) conditions on the scale of kilograms is reported. The availability of GMP-grade HI-443 will promote the preclinical and clinical development efforts aimed at making this new drug candidate available to HIV-infected persons. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0031-1296627.pdf |
| Ending Page | 338 |
| Page Count | 9 |
| Starting Page | 330 |
| ISSN | 00044172 |
| e-ISSN | 16167066 |
| DOI | 10.1055/s-0031-1296627 |
| Journal | Arzneimittelforschung |
| Issue Number | 06 |
| Volume Number | 57 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2007-06-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Arzneimittelforschung Medicinal Chemistry Pharmacology and Pharmacy N'-[2-(2-thiophene)ethyl]-n'-[2-(5-bromopyridyl)]-thiourea Non-nucleoside Analog Reverse Transcriptase Inhibitors |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery |
