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Anti-retroviral Activity of GMP-Grade Stampidine against Genotypically and Phenotypically Nucleoside Reverse Transcriptase Inhibitor Resistant Recombinant Human Immunodeficiency Virus
| Content Provider | Scilit |
|---|---|
| Author | Uckun, Fatih M. DuMez, Darin Qazi, Sanjive Tibbies, Heather Venkatachalam, Taracad K. |
| Copyright Year | 2007 |
| Description | The in vitro potency of GMP-grade stampidine (CAS 217178-62-6) was examined against 3 clinical HIV-1 isolates and 6 recombinant HIV-1 clones with multi-NRTI resistance (NRTI: nucleoside reverse transcriptase inhibitors). GMP-grade stampidine active drug substance (Lot #'s MPR-M0008.00-01 and MPR-M0008.01-01) as well as GMP-grade stampidine extracted from the clinical stampidine capsules (GMP-Grade Clinical Batch, Pharmaceutical Service Lot Number 15910601) were highly potent and exhibited nanomolar IC50 values against clinical HIV-1 isolates as well as recombinant HIV-1 clones with multi-NRTI resistance containing common patterns of reverse transcriptase mutations responsible for NRTI resistance. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0031-1296592.pdf |
| Ending Page | 121 |
| Page Count | 10 |
| Starting Page | 112 |
| ISSN | 00044172 |
| e-ISSN | 16167066 |
| DOI | 10.1055/s-0031-1296592 |
| Journal | Arzneimittelforschung |
| Issue Number | 02 |
| Volume Number | 57 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2007-02-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Arzneimittelforschung Pharmacology and Pharmacy Human Immunodeficiency Virus Nucleoside Reverse Transcriptase Inhibitors Antiretroviral Activity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery |