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NovelC$ _{2}$-Symmetric 1,1′-Disubstituted Ferrocenyl Aziridino Alcohol Ligands: Remarkable Improvement of Enantioselectivity in the Catalytic Asymmetric Addition of Diethylzinc to Aldehydes
| Content Provider | Scilit |
|---|---|
| Author | Wang, Min-Can Hou, Xue-Hui Xu, Cui-Lian Liu, Lan-Tao Li, Gui-Lan Wang, De-Kun |
| Copyright Year | 2005 |
| Description | A series of novel chiral C$ _{2}$-symmetric 1,1′-disubstituted ferrocenyl aziridino alcohols have been readily synthesized and applied as catalysts to promote enantioselective addition of diethylzinc to aldehydes affording the corresponding 1-propanols in up to 99.5% enantiomeric excess with excellent yields. The effect of the ligand structure on the enantioselectivity was examined. The results showed that the C$ _{2}$-symmetric ferrocenyl β-amino alcohol ligands could produce an excellent asymmetric environment for the asymmetric addition of diethylzinc to aldehydes. The absolute configuration of chiral C$ _{2}$-symmetric ferrocenyl aziridino alcohol ligand 8j was confirmed by X-ray diffraction analysis. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2005-916038.pdf |
| Ending Page | 3626 |
| Page Count | 7 |
| Starting Page | 3620 |
| ISSN | 00397881 |
| e-ISSN | 1437210X |
| DOI | 10.1055/s-2005-916038 |
| Journal | Synthesis |
| Issue Number | 20 |
| Volume Number | 2005 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2005-10-12 |
| Access Restriction | Open |
| Subject Keyword | Journal: Synthesis Organic Chemistry Aziridino Alcohols Asymmetric Addition |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Catalysis |
