Novel C2-Symmetric 1,1′-Disubstituted Ferrocenyl Aziridino Alcohol Ligands: Remarkable Improvement of Enantioselectivity in the Catalytic Asymmetric Addition of Diethylzinc to Aldehydes.

Content Provider	Semantic Scholar
Author	Wang, Min-Can Hou, Xue-Hui Xu, Cuilian Liu, Lantao Li, Gui-Lan Wang, De-Kun
Copyright Year	2006
Abstract	SYNTHESIS 2005, No. 20, pp 3620–3626xx.xx.2005 Advanced online publication: 12.10.2005 DOI: 10.1055/s-2005-916038; Art ID: F09705SS © Georg Thieme Verlag Stuttgart · New York Abstract: A series of novel chiral C2-symmetric 1,1¢-disubstituted ferrocenyl aziridino alcohols have been readily synthesized and applied as catalysts to promote enantioselective addition of diethylzinc to aldehydes affording the corresponding 1-propanols in up to 99.5% enantiomeric excess with excellent yields. The effect of the ligand structure on the enantioselectivity was examined. The results showed that the C2-symmetric ferrocenyl b-amino alcohol ligands could produce an excellent asymmetric environment for the asymmetric addition of diethylzinc to aldehydes. The absolute configuration of chiral C2-symmetric ferrocenyl aziridino alcohol ligand 8j was confirmed by X-ray diffraction analysis.
Starting Page	3620
Ending Page	3626
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1002/chin.200620030
Volume Number	37
Alternate Webpage(s)	http://www.xiuzhengrd.com/ejournals/pdf/synthesis/doi/10.1055/s-2005-916038.pdf
Alternate Webpage(s)	https://doi.org/10.1002/chin.200620030
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article