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Essential Thrombocythemia/Polycythemia Vera and Pregnancy: The Need for an Observational Study in Europe
| Content Provider | Scilit |
|---|---|
| Author | Griesshammer, Martin Struve, Sabine Harrison, Claire |
| Copyright Year | 2006 |
| Description | The management of pregnant patients with essential thrombocythemia (ET) and polycythemia vera (PV) may be problematic. In the literature there are ~300 cases of pregnancies reported in ET and less than 50 pregnancies reported in PV. To reduce the effect of reporting bias, we selected articles with either > 10 pregnancies or at least six patients, and here report on the outcome of 195 pregnancies in ET and 36 pregnancies in PV patients. The live birth rate was ~60% in ET and 58% in PV. Spontaneous abortion during the first trimester was the most frequent fetal complication, occurring in 31% of ET pregnancies and in 22% of PV pregnancies, respectively. Major maternal complications were more frequent in PV compared with ET (44.4 versus 7.7%). Treatment with low-dose aspirin during pregnancy in ET seemed to reduce complications and also seemed beneficial during pregnancy in PV. In high-risk pregnancies, the additional use of low molecular weight heparin and/or interferon α should be considered. This article also describes a registry for an observational study concerning pregnancy in chronic Philadelphia chromosome-negative myeloproliferative disorders within the European LeukemiaNet. A potential management algorithm for pregnancies in ET or PV is also provided. |
| Related Links | http://pdfs.semanticscholar.org/7753/e82eb475e4854ef1421850a42f8ab991854a.pdf http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2006-942763.pdf |
| Ending Page | 429 |
| Page Count | 8 |
| Starting Page | 422 |
| ISSN | 00946176 |
| e-ISSN | 10989064 |
| DOI | 10.1055/s-2006-942763 |
| Journal | Seminars in Thrombosis and Hemostasis |
| Issue Number | 4 |
| Volume Number | 32 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2006-06-29 |
| Access Restriction | Open |
| Subject Keyword | Journal: Seminars in Thrombosis and Hemostasis Keywordsessential Thrombocythemia Polycythemia Vera Observational Study European Leukemianet |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology Cardiology and Cardiovascular Medicine |
