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Five New Triterpenoid Saponins from the Rhizomes of Panacis majoris and Their Antiplatelet Aggregation Activity
| Content Provider | Scilit |
|---|---|
| Author | Li, Min Liu, Fen Jin, Yong-Ri Wang, Xiao-Zhong Wu, Qian Liu, Ying Li, Xu-Wen |
| Copyright Year | 2016 |
| Description | Five new triterpenoid saponins (1–5) and four known triterpenoid saponins, ginsenoside $Re_{5}$ (6), majonoside $R_{1}$ (7), 24(R)-majonoside $R_{1}$ (8), and ginsenoside Rf (9), were isolated from the rhizomes of Panacis majoris. The structures of new compounds were elucidated as (20S,24S,25R*)-6-O-[β-D-glucopyranosyl-(1 → 2)-β-D-glucopyranosyl]-dammar-20,24-epoxy-3β,6α,12β,25,26-pentaol (1), (20S,24R,25R)-6-O-[β-D-glucopyranosyl-(1 → 2)-β-D-glucopyranosyl]-dammar-20,24-epoxy-3β,6α,12β,25,26-pentaol (2), (20S)-6-O-[β-D-glucopyranosyl-(1 → 2)-β-D-glucopyranosyl]-dammar-20,25-epoxy-3β,6α,12β,24α-tetraol (3), 6-O-[β-D-glucopyranosyl-(1 → 2)-β-D-glucopyranosyl]-dammar-3β,6α,12β,20S,24R,25-hexaol (4), and 6-O-[β-D-glucop-yranosyl-(1 → 2)-β-D-glucopyranosyl]-dammar-25(26)-ene-3β,6α,12β,20S,24R-pentaol (5) on the basis of extensive spectral analysis and chemical methods. Ginsenoside $Re_{5}$ was isolated from the plant for the first time. The similarities of the nine compounds lie in the fact that their aglycones are conjoined with the same glucopyranose moieties, the same linkage of the glycosyl chains, and the same glycosylation sites, while they have a varied C-17 side chain. Compounds 3 and 5 exhibited moderate antiplatelet aggregation activities induced by adenosine diphosphate with $IC_{50}$ values of 23.24 and 18.43 µM, respectively. Compound 5 displayed moderate inhibition of arachidonic acid-induced platelet aggregation with an $IC_{50}$ value of 30.11 µM. |
| Related Links | http://pdfs.semanticscholar.org/f620/c1b27cd1d2c28ad2a3abf8c7963414f38b93.pdf http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0042-117554.pdf |
| Ending Page | 357 |
| Page Count | 7 |
| Starting Page | 351 |
| ISSN | 00320943 |
| e-ISSN | 14390221 |
| DOI | 10.1055/s-0042-117554 |
| Journal | Planta Medica |
| Issue Number | 03/04 |
| Volume Number | 83 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2016-09-27 |
| Access Restriction | Open |
| Subject Keyword | Journal: Planta Medica Integrative and Complementary Medicine Panacis Majoris Triterpenoid Saponins Antiplatelet Aggregation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Analytical Chemistry Molecular Medicine Pharmacology Complementary and Alternative Medicine Pharmaceutical Science |
