NDLI: Selective Synthesis of 2- and 7-Substituted Indole Derivatives via Chelation-Assisted Metallocarbenoid C

Please wait, while we are loading the content...

Selective Synthesis of 2- and 7-Substituted Indole Derivatives via Chelation-Assisted Metallocarbenoid C–H Bond Functionalization

Content Provider	Scilit
Author	Osipov, Sergey N. Vorobyeva, Daria V.
Copyright Year	2017
Description	Functionally substituted indole derivatives are important intermediates for the synthesis of new potential drug candidates exhibiting strong bioactivities. Over the past few years, significant progress has been made in the direct C–H functionalization of the indole ring through the usage of metal-catalyzed intermolecular cross-coupling with diazo compounds. Directing group strategy provides a unique possibility for selective insertion of carbenes catalytically generated from diazo compounds into challenging indole C2–H and C7–H bonds. This short review summarizes recent advances in carbenoid functionalization of indole derivatives under chelation-controlled metal catalysis.1 Introduction2 Indole C2 Alkylation with α-Diazotized Meldrum’s Acid3 Indole C2 Alkylation with Diazomalonate Derivatives and Related Compounds4 Indole C7 Alkylation with Diazomalonates and Related Compounds5 Tandem Indole C2–H Alkylation/Cyclization6 Indoline C7 Alkylation with Diazomalonates and Related Compounds7 Tandem Indoline C7–H Alkylation/Cyclization8 Conclusion
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0036-1591498.pdf
Ending Page	240
Page Count	14
Starting Page	227
ISSN	00397881
e-ISSN	1437210X
DOI	10.1055/s-0036-1591498
Journal	Synthesis
Issue Number	02
Volume Number	50
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2017-10-19
Access Restriction	Open
Subject Keyword	Journal: Synthesis Organic Chemistry Diazo Compounds C–h Functionalization Metal Catalysis
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Catalysis

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Recent advances in C(sp3)–H bond functionalization via metal–carbene insertions

Transition-Metal-Catalyzed C-H Functionalization for the Synthesis of Substituted Pyridines

Iridium(III)-Catalyzed C−H Functionalization of Triarylphosphine Oxides with Diazo Dicarbonyl Compounds: Synthesis of α-Aryl 1,3-Dicarbonyl Derivatives

Palladium-Catalyzed Chelation-Assisted C–H Bond Halogenation: Selective Chlorination of 2-Arylpyridines with Acid Chlorides

Transition-Metal-Catalyzed Synthesis of Aromatic Ketones via Direct C-H Bond Activation

Directing group-assisted transition-metal-catalyzed vinylic C-H bond functionalization

Rhodium Catalyzed Chelation-Assisted C–H Bond Functionalization Reactions

Regioselective Monoarylation of 2-Phenylbenzimidazole via Ruthenium-Catalyzed C–H Bond Functionalization

Selective C–Si Bond Formation through C–H Functionalization

Selective Synthesis of 2- and 7-Substituted Indole Derivatives via Chelation-Assisted Metallocarbenoid C–H Bond Functionalization

Similar Documents

Recent advances in C(sp3)–H bond functionalization via metal–carbene insertions

Transition-Metal-Catalyzed C-H Functionalization for the Synthesis of Substituted Pyridines

Iridium(III)-Catalyzed C−H Functionalization of Triarylphosphine Oxides with Diazo Dicarbonyl Compounds: Synthesis of α-Aryl 1,3-Dicarbonyl Derivatives

Palladium-Catalyzed Chelation-Assisted C–H Bond Halogenation: Selective Chlorination of 2-Arylpyridines with Acid Chlorides

Transition-Metal-Catalyzed Synthesis of Aromatic Ketones via Direct C-H Bond Activation

Directing group-assisted transition-metal-catalyzed vinylic C-H bond functionalization

Rhodium Catalyzed Chelation-Assisted C–H Bond Functionalization Reactions

Regioselective Monoarylation of 2-Phenylbenzimidazole via Ruthenium-Catalyzed­ C–H Bond Functionalization

Selective C–Si Bond Formation through C–H Functionalization

Selective Synthesis of 2- and 7-Substituted Indole Derivatives via Chelation-Assisted Metallocarbenoid C–H Bond Functionalization

Regioselective Monoarylation of 2-Phenylbenzimidazole via Ruthenium-Catalyzed C–H Bond Functionalization