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Antiviral, Haemolytic and Molluscicidal Activities of Triterpenoid Saponins from Maesa lanceolata: Establishment of Structure-Activity Relationships
| Content Provider | Scilit |
|---|---|
| Author | Apers, Sandra Baronikova, Slavka Sindambiwe, Jean-Bosco Witvrouw, Myriam Clercq, Erik Berghe, Dirk Marck, Eric Vlietinck, Arnold Pieters, Luc |
| Copyright Year | 2001 |
| Description | Ten saponins isolated from the leaves of Maesa lanceolata were tested for their antiviral, haemolytic and molluscicidal activities. The influence of the substitution pattern of these acylated triterpenoid saponins on their biological activities was investigated and structure-activity relationships were established. Maesasaponin $VI_{2}$ (3β-O-{[α-L-rhamnopyranosyl-(1 → 2)-β-D-galactopyranosyl-(1 → 3)]-[β-D-galactopyranosyl-(1 → 2)]-β-D-glucopyranuronyl}-21β,22α-diangeloyloxy-13 β,28-epoxyolean-16α,28α-diol), the most potent molluscicidal compound $(LC_{50}$ 0.5 ppm), also showed virucidal and haemolytic activity. In general, 21,22-diacylation appeared to be associated with a virucidal (reduction factor of the viral titer ≥ $10^{3}$ at 50 μg/ml) and haemolytic activity $(HC_{50}$ ≤ 1 μg/ml). |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2001-16489.pdf |
| Ending Page | 532 |
| Page Count | 5 |
| Starting Page | 528 |
| ISSN | 00320943 |
| e-ISSN | 14390221 |
| DOI | 10.1055/s-2001-16489 |
| Journal | Planta Medica |
| Issue Number | 06 |
| Volume Number | 67 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2001-08-17 |
| Access Restriction | Open |
| Subject Keyword | Journal: Planta Medica Integrative and Complementary Medicine Maesa Lanceolata Triterpenoid Saponins Saponin Esters Antiviral Activity Haemolytic Activity Molluscicidal Activity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Analytical Chemistry Molecular Medicine Pharmacology Complementary and Alternative Medicine Pharmaceutical Science |
