Loading...
Please wait, while we are loading the content...
A new tool for sepsis screening in the Emergency Department
| Content Provider | Scilit |
|---|---|
| Author | Agnello, Luisa Iacona, Alessandro Sasso, Bruna Lo Scazzone, Concetta Pantuso, Michele Giglio, Rosaria Vincenza Gambino, Caterina Maria Ciaccio, Anna Maria Bivona, Giulia Vidali, Matteo Ciaccio, Marcello |
| Copyright Year | 2021 |
| Abstract | Objectives In this study, we developed and evaluated the diagnostic accuracy of the Sepsis Index for early sepsis screening in the Emergency Department (ED). Methods Sepsis Index is based on the combination of monocyte distribution width (MDW) and mean monocyte volume (MMV). Sepsis Index≥1 was selected to define sepsis. We tested its diagnostic accuracy in an ED population stratified in four groups: controls, Systemic Inflammatory Response Syndrome (SIRS), infection, and sepsis, according to Sepsis-2 criteria. Results Patients with sepsis displayed higher median Sepsis Index value than patients without sepsis. At the receiver operating characterictis (ROC) curve analysis for the prediction of sepsis, the area under the curve (AUC) of MDW and Sepsis Index were similar: 0.966 (95%CI 0.947–0.984), and 0.964 (95%CI 0.942–0.985), respectively. Sepsis Index showed increased specificity than MDW (94.7 vs. 90.6%), without any decrease in sensitivity (92.0%). Additionally, LR+ increased from 9.8 (MDW) to 17.4 (Sepsis Index), without any substantial change in LR− (respectively 0.09 vs. 0.08). Finally, PPV increased from 0.286 (MDW) to 0.420 (Sepsis Index). Conclusions Sepsis Index improves the diagnostic accuracy of MDW alone for sepsis screening. |
| Related Links | https://www.degruyter.com/document/doi/10.1515/cclm-2021-0208/pdf |
| Ending Page | 1605 |
| Page Count | 6 |
| Starting Page | 1600 |
| ISSN | 14346621 |
| e-ISSN | 14374331 |
| DOI | 10.1515/cclm-2021-0208 |
| Journal | Clinical Chemistry and Laboratory Medicine (CCLM) |
| Issue Number | 9 |
| Volume Number | 59 |
| Language | English |
| Publisher | Walter de Gruyter GmbH |
| Publisher Date | 2021-08-26 |
| Access Restriction | Open |
| Subject Keyword | Clinical Chemistry and Laboratory Medicine (cclm) Emergency Medicine Biomarker Emergency Department Mean Monocyte Volume (mmv) Monocyte Distribution Width (mdw) Sepsis Journal: Clinical Chemistry and Laboratory Medicine (CCLM), Vol- 59 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Clinical Biochemistry |
