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Monocyte distribution width (MDW) as a screening tool for sepsis in the Emergency Department
| Content Provider | Scilit |
|---|---|
| Author | Agnello, Luisa Bivona, Giulia Vidali, Matteo Scazzone, Concetta Giglio, Rosaria Vincenza Iacolino, Giorgia Iacona, Alessandro Mancuso, Silvia Ciaccio, Anna Maria Sasso, Bruna Lo Ciaccio, Marcello |
| Copyright Year | 2020 |
| Abstract | Objectives: The diagnosis of sepsis in the Emergency Department (ED) is challenging and a reliable biomarker is needed. The current study aimed to evaluate the diagnostic accuracy of monocyte distribution width (MDW) for the early identification of sepsis in the ED. Methods: We performed a large observational study including consecutive adult patients (≥18 years of age) presenting to the ED between September and November 2019, with an order for complete blood count (CBC) evaluation. A total of 2,215 patients were enrolled and classified based on Sepsis-2 criteria as the control group (1,855), infection group (172), Systemic Inflammatory Response Syndrome (SIRS) group (100), and sepsis group (88). Results: MDW levels were higher in patients with sepsis than in all other groups (p<0.001). ROC curve analysis showed an optimal diagnostic accuracy of MDW for sepsis prediction at a cut-off point of 23.5, with an AUC of 0.964, sensitivity and specificity of 0.920 and 0.929, respectively. Conclusions: Our findings encourage further investigation to validate the use of MDW as a screening tool for the early identification of patients at risk of sepsis in the ED. |
| Related Links | https://www.degruyter.com/downloadpdf/journals/cclm/ahead-of-print/article-10.1515-cclm-2020-0417/article-10.1515-cclm-2020-0417.pdf |
| Ending Page | 1957 |
| Page Count | 7 |
| Starting Page | 1951 |
| ISSN | 14346621 |
| e-ISSN | 14374331 |
| DOI | 10.1515/cclm-2020-0417 |
| Journal | Clinical Chemistry and Laboratory Medicine (CCLM) |
| Issue Number | 11 |
| Volume Number | 58 |
| Language | English |
| Publisher | Walter de Gruyter GmbH |
| Publisher Date | 2020-05-15 |
| Access Restriction | Open |
| Subject Keyword | Clinical Chemistry and Laboratory Medicine (cclm) Emergency Medicine Emergency Department (ed) Infection Monocytes Monocyte Distribution Width (mdw) Screening Sepsis Journal: Clinical Chemistry and Laboratory Medicine (CCLM), Issue- 1-3 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Clinical Biochemistry |
