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Five genetic polymorphisms of cytochrome P450 enzymes in the Czech non-Roma and Czech Roma population samples
| Content Provider | Scilit |
|---|---|
| Author | Dlouhá, Lucie Adámková, Věra Šedová, Lenka Olišarová, Věra Hubáček, Jaroslav A. Tóthová, Valérie |
| Copyright Year | 2020 |
| Abstract | Objectives: Cytochromes P450 play a role in human drugs metabolic pathways and their genes are among the most variable in humans. The aim of this study was to analyze genotype frequencies of five common polymorphisms of cytochromes P450 in Roma/Gypsy and Czech (non-Roma) population samples with Czech origin. Methods: Roma/Gypsy (n=302) and Czech subjects (n=298) were genotyped for CYP1A2 (rs762551), CYP2A6 (rs4105144), CYP2B6 (rs3745274) and CYP2D6 (rs3892097; rs1065852) polymorphisms using PCR-RFLP or Taqman assay. Results: We found significant allelic/genotype differences between ethnics in three genes. For rs3745274 polymorphism, there was increased frequency of T allele carriers in Roma in comparison with Czech population (53.1 vs. 43.7%; p=0.02). For rs4105144 (CYP2A6) there was higher frequency of T allele carriers in Roma in comparison with Czech population (68.7 vs. 49.8%; p<0.0001). For rs3892097 (CYP2D6) there was more carriers of the A allele between Roma in comparison with Czech population (39.2 vs. 38.2%; p=0.048). Genotype/allelic frequencies of CYP2D6 (rs1065852) and CYP1A2 (rs762551) variants did not significantly differ between the ethnics. Conclusions: There were significant differences in allelic/genotype frequencies of some, but not all cytochromes P450 polymorphisms between the Czech Roma/Gypsies and Czech non-Roma subjects. |
| Related Links | https://www.degruyter.com/downloadpdf/journals/dmdi/ahead-of-print/article-10.1515-dmdi-2020-0103/article-10.1515-dmdi-2020-0103.pdf |
| ISSN | 23638907 |
| e-ISSN | 23638915 |
| DOI | 10.1515/dmdi-2020-0103 |
| Journal | Drug metabolism and personalized therapy |
| Language | English |
| Publisher | Walter de Gruyter GmbH |
| Publisher Date | 2020-06-30 |
| Access Restriction | Open |
| Subject Keyword | Drug Metabolism and Personalized Therapy Rheumatology Cytochromes P450 Czech Majority Polymorphism Roma/gypsy Journal: Drug metabolism and personalized therapy, Vol- 1 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology, Toxicology and Pharmaceutics Pharmacology (medical) |
