NDLI: Differences of hexarelin-induced prolactin and cortisol responses between prepubertal and early pubertal short children and lack of correlation with gonadotropin-releasing hormone-induced gonadotropin response.

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Differences of hexarelin-induced prolactin and cortisol responses between prepubertal and early pubertal short children and lack of correlation with gonadotropin-releasing hormone-induced gonadotropin response.

Content Provider	Scilit
Author	Guzzaloni, G. Grugni, G. Morabito, F.
Copyright Year	2000
Abstract	Hexarelin (HEX), a synthetic hexapeptide with strong GH-stimulating activity, is known to induce the release of prolactin (PRL) and cortisol (F). The responses of GH and F vary according to age and pubertal development, correlating with serum levels of sex steroids, while the release of PRL does not. We evaluated GH, PRL and F responses to HEX (2 microg/kg i.v.) in 19 children with short stature, 12 prepubertal (Tanner stage I) and 7 early pubertal (stage II), and their correlation with those of FSH and LH to GnRH and with the serum levels of testosterone (T) or estradiol (E2). At baseline, the GH, PRL, F and sex steroid serum levels did not vary in the two groups of patients. HEX induced a strong GH and a slight PRL increase in prepubertal and early pubertal children, with no differences in the extent of the response, while F secretion was not affected in either group; these responses did not correlate with those of the gonadotropins to GnRH nor with basal T or E2.
Related Links	http://www.degruyter.com/downloadpdf/j/jpem.2000.13.7/jpem.2000.13.7.907/jpem.2000.13.7.907.xml
Ending Page	912
Page Count	6
Starting Page	907
ISSN	21910251
DOI	10.1515/jpem.2000.13.7.907
Journal	Journal of Pediatric Endocrinology and Metabolism
Issue Number	7
Volume Number	13
Language	English
Publisher	Walter de Gruyter GmbH
Publisher Date	2000-01-01
Access Restriction	Open
Subject Keyword	Journal of Pediatric Endocrinology and Metabolism Pediatrics and Child Health Gonadotropin Hex Pubertal Children Early Pubertal Short Children Prepubertal and Early Pubertal Journal: Journal of Pediatric Endocrinology and Metabolism, Issue- 10
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Endocrinology Pediatrics, Perinatology and Child Health

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