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Growth Hormone Release by the Novel GH Releasing Peptide Hexarelin in Patients with Homozygous β-Thalassemia

Content Provider	Scilit
Author	Toli, G. Karydis, I. Markousis, V. Karagiorga, M. Mesimeris, T. Lenaerts, V. Deghenghi, R.
Copyright Year	1997
Abstract	Patients with beta-thalassemia often present with abnormalities in growth and other endocrine functions. Growth hormone (GH) secretion is controlled via somatostatin and growth hormone releasing hormone (GHRH). Recently, Hexarelin, a new potent GH secretagogue (His-D-2-Methyl-Trp-Ala-Trp-D-Phe-Lys-NH2), was synthesized. Our study was designed to assess and compare its efficacy as a GH secretagogue to GHRH 1-29 in beta-thalassemia. Eighteen patients, regularly transfused and chelated, were studied; 11 were short statured. None had diabetes mellitus, hypothyroidism, hypopara-thyroidism or major organ failure. We measured GH at 0, 30, 60, 90, 120 min after GHRH 1-29 or Hexarelin administration. Hexarelin p.o. or i.v. evoked a brisk rise of serum GH which was significantly higher (p < 0.01) than that induced by GHRH 1-29 i.v. In conclusion, Hexarelin has greater GH releasing capacity than GHRH 1-29 at 1 microgram/kg i.v. and can thus be viewed as a potential therapeutic agent in GH deficient states.
Related Links	http://www.degruyter.com/downloadpdf/j/jpem.1997.10.1/jpem.1997.10.1.35/jpem.1997.10.1.35.xml
Ending Page	40
Page Count	6
Starting Page	35
ISSN	21910251
DOI	10.1515/jpem.1997.10.1.35
Journal	Journal of Pediatric Endocrinology and Metabolism
Issue Number	1
Volume Number	10
Language	English
Publisher	Walter de Gruyter GmbH
Publisher Date	1997-01-01
Access Restriction	Open
Subject Keyword	Journal of Pediatric Endocrinology and Metabolism Endocrinology and Metabolism Diabetes Trp Efficacy Growth Hormone I.v Secretagogue Hormone Releasing Hexarelin Journal: Journal of Pediatric Endocrinology and Metabolism, Issue- 3
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Endocrinology Pediatrics, Perinatology and Child Health

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