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Changes in glutathione status and 3,5,3'-triiodothyronine action in livers of rats given cysteine-deficient diets
| Content Provider | Scilit |
|---|---|
| Author | Garcin, H. Suberville, C. Higueret, P. |
| Copyright Year | 1989 |
| Description | 1. For a period of 32 d young rats were given a diet containing (g/kg) 220 casein, 120 casein +1.93 L-cysteine (Cys), or 120 casein.2. The formation of 3,5,3'-triiodothyronine $(T_{3}$)-nuclear protein complexes was reduced in rats fed on the Cys-deficient diet.3. Scatchard analysis showed that decreased formation of $T_{3}$-nuclear protein complexes was due to a decreased affinity of $T_{3}$receptors; this decrease was induced, at least in part, by a reduced glutathione content.4. In rats fed on the Cys-deficient diet there was an expected decrease in growth but an unexpected increase in the activities of glucose-6-phosphate dehydrogenase (EC1.1.1.49) and malate dehydrogenase (oxaloacetate-decarboxylating) $(NADP^{+}$) (EC1.1.1.40). It is suggested that this increase is related to an increased oxidized glutathione: reduced glutathione ratio. |
| Related Links | http://pdfs.semanticscholar.org/2575/165780333e6b8889701192deb1e54f38d7bf.pdf https://www.cambridge.org/core/services/aop-cambridge-core/content/view/A4108568BA8E45AB2CA896206E23E5E5/S0007114589000371a.pdf/div-class-title-changes-in-glutathione-status-and-3-5-3-triiodothyronine-action-in-livers-of-rats-given-cysteine-deficient-diets-div.pdf |
| Ending Page | 307 |
| Page Count | 7 |
| Starting Page | 301 |
| ISSN | 00071145 |
| e-ISSN | 14752662 |
| DOI | 10.1079/bjn19890118 |
| Journal | British Journal Of Nutrition |
| Issue Number | 2 |
| Volume Number | 61 |
| Language | English |
| Publisher | Cambridge University Press (CUP) |
| Publisher Date | 1989-03-09 |
| Access Restriction | Open |
| Subject Keyword | British Journal Of Nutrition Nutrition and Dietetics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Medicine |
