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Intestinal β-carotene 15,15′-dioxygenase activity is markedly enhanced in copper-deficient rats fed on high-iron diets and fructose
| Content Provider | Scilit |
|---|---|
| Author | During, Alexandrine Fields, Meira Lewis, Charles G. Smith, J. Cecil |
| Copyright Year | 2000 |
| Description | The purpose of the present work was to examine effects of the Cu–Fe interaction on intestinal β-carotene 15,15′-dioxygenase activity when a wide range of dietary Fe (deficiency to excess) was used in relation to Cu status of rats. The effect of dietary carbohydrates was also examined since they play a role in the Cu–Fe interactionin vivo. Weanling male Sprague-Dawley rats (n72) were divided into twelve dietary groups, which were fed on either low-, normal-, or high-Fe levels (0·9, 9·0, and 90·0 mmol Fe/kg diet respectively) combined with Cu-adequate or -deficient levels (0·94 and 0·09 mmol Cu/kg diet respectively) and with starch or fructose in the diets. The data showed that both Fe concentration and β-carotene 15,15′-dioxygenase activity in small intestinal mucosa were enhanced with increasing dietary Fe and with Cu deficiencyv. Cu adequacy. Dietary fructose did not aggravate the Fe-enhancement, related to Cu deficiency, in the small intestine; however, fructose increased the intestinal dioxygenase activity in rats fed on normal- or high-Fe diets when compared with starch controls. Thus, the highest intestinal dioxygenase activity associated with the lowest hepatic retinol (total) concentration was found in rats fed on the Cu-deficient, high-Fe, fructose-based diet. Finally, a positive linear relationship was found between the dioxygenase activity and Fe concentration in intestinal mucosa. In conclusion, the data indicate that β-carotene 15,15′-dioxygenase activity requires Fe as cofactorin vivoand the enzyme is modulated by the three dietary components: Cu, Fe, and fructose. |
| Related Links | https://www.cambridge.org/core/services/aop-cambridge-core/content/view/7CBFB8E63EA5EB54627955756B37CD61/S0007114500001306a.pdf/div-class-title-intestinal-carotene-15-15-dioxygenase-activity-is-markedly-enhanced-in-copper-deficient-rats-fed-on-high-iron-diets-and-fructose-div.pdf |
| Ending Page | 124 |
| Page Count | 8 |
| Starting Page | 117 |
| ISSN | 00071145 |
| e-ISSN | 14752662 |
| DOI | 10.1017/s0007114500001306 |
| Journal | British Journal Of Nutrition |
| Issue Number | 1 |
| Volume Number | 84 |
| Language | English |
| Publisher | Cambridge University Press (CUP) |
| Publisher Date | 2000-07-01 |
| Access Restriction | Open |
| Subject Keyword | British Journal Of Nutrition Nutrition and Dietetics carotene 15 dioxygenase Activity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Medicine |
