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Effects of plant sterol esters in skimmed milk and vegetable-fat-enriched milk on serum lipids and non-cholesterol sterols in hypercholesterolaemic subjects: a randomised, placebo-controlled, crossover study
| Content Provider | Scilit |
|---|---|
| Author | Casas-Agustench, Patricia Serra, Mercè Pérez-Heras, Ana Cofán, Montserrat Pintó, Xavier Trautwein, Elke A. Ros, Emilio |
| Copyright Year | 2011 |
| Description | Plant sterol (PS)-supplemented foods are recommended to help in lowering serum LDL-cholesterol (LDL-C). Few studies have examined the efficacy of PS-enriched skimmed milk (SM) or semi-SM enriched with vegetable fat (PS-VFM). There is also insufficient information on factors predictive of LDL-C responses to PS. We examined the effects of PS-SM (0·1 % dairy fat) and PS-VFM (0·1 % dairy fat plus 1·5 % vegetable fat) on serum lipids and non-cholesterol sterols in hypercholesterolaemic individuals. In a placebo-controlled, crossover study, forty-three subjects with LDL-C>1300 mg/l were randomly assigned to three 4-week treatment periods: control SM, PS-SM and PS-VFM, with 500 ml milk with or without 3·4 g PS esters (2 g free PS). Serum concentrations of lipids and non-cholesterol sterols were measured. Compared to control, LDL-C decreased by 8·0 and 7·4 % (P < 0·015, both) in the PS-SM and PS-VFM periods, respectively. Serum lathosterol:cholesterol (C) ratios increased by 11–25 %, while sitosterol:C and campesterol:C ratios increased by 70–120 % with both the PS-fortified milk. Adjusted LDL-C reductions were variably enhanced in participants with basal low serum lathosterol/C or conversely high sitosterol/C and campesterol/C. Subjects with post-treatment serum PS:C ratios above the median showed mean LDL-C changes of − 5·9 to − 10·4 %, compared with 1·7 to − 2·9 % below the median. In conclusion, consumption of 2 g/d of PS as PS-SM and PS-VFM lowered LDL-C in hypercholesterolaemic subjects to a similar extent. Basal and post-treatment changes in markers of cholesterol metabolism indicating low cholesterol synthesis and high cholesterol absorption predicted improved LDL-C responses to PS. |
| Related Links | https://www.cambridge.org/core/services/aop-cambridge-core/content/view/5CDEEEA51AB41AD83CB4B6B175923618/S0007114511005162a.pdf/div-class-title-effects-of-plant-sterol-esters-in-skimmed-milk-and-vegetable-fat-enriched-milk-on-serum-lipids-and-non-cholesterol-sterols-in-hypercholesterolaemic-subjects-a-randomised-placebo-controlled-crossover-study-div.pdf |
| Ending Page | 1775 |
| Page Count | 10 |
| Starting Page | 1766 |
| ISSN | 00071145 |
| e-ISSN | 14752662 |
| DOI | 10.1017/s0007114511005162 |
| Journal | British Journal Of Nutrition |
| Issue Number | 12 |
| Volume Number | 107 |
| Language | English |
| Publisher | Cambridge University Press (CUP) |
| Publisher Date | 2011-10-10 |
| Access Restriction | Open |
| Subject Keyword | British Journal Of Nutrition Nutrition and Dietetics Serum Lipids Ps Vfm Hypercholesterolaemic Subjects |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Medicine |
