NDLI: Effect of graft-versus-host disease on hematopoiesis after bone marrow transplantation in mice

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Effect of graft-versus-host disease on hematopoiesis after bone marrow transplantation in mice

Content Provider	Scilit
Author	Dijken, Pj Van Wimperis, J. Crawford, Jm Ferrara, Jl
Copyright Year	1991
Description	We have examined the effect of graft-versus-host disease (GVHD) on the reconstitution of donor hematopoiesis in a murine bone marrow transplant (BMT) model of GVHD to minor histocompatibility antigens. GVHD had no effect on peripheral blood counts, which normalized by 1 month after BMT, and did not affect numbers of hematopoietic progenitors in the BM, which remained decreased in all transplant recipients. Donor stem cells (colony-forming unit-spleen day 8) and stem cell self-renewal remained low in all mice for 5 months after transplant, but GVHD further damaged the stem cell compartment. Peripheral counts 1 month after transplant were supported by increased numbers of stem cells in cycle and increased splenic hematopoiesis. However, GVHD altered the pattern of extramedullary hematopoiesis, causing dramatically decreased activity in the spleen and increased activity in the liver. We conclude that GVHD further decreases hematopoietic reserve and causes damage to the donor stem cell compartment during hematopoietic reconstitution after transplant, despite unaffected progenitor frequencies and peripheral blood counts.
Related Links	https://ashpublications.org/blood/article-pdf/78/10/2773/222189/2773.pdf
Ending Page	2779
Page Count	7
Starting Page	2773
DOI	10.1182/blood.v78.10.2773.bloodjournal78102773
Journal	Blood
Issue Number	10
Volume Number	78
Language	English
Publisher	American Society of Hematology
Publisher Date	1991-11-15
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Hematopoietic Graft Transplant Bone Marrow Model Antigens Gvhd Hematopoiesis Bmt Donor Journal: Blood (Vol- 111, Issue- 10)
Content Type	Text
Resource Type	Article

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